Abilev S K, Liubimova I K, Migachev G I
Genetika. 1993 Oct;29(10):1640-5.
Comparative mutagenic activity of 7 derivatives of biphenyl and fluorenone, 4,4'-dinitrobiphenyl-2,2'-dicarboxylic acid; 4,4',6,6'-tetranitrobiphenyl-2,2'-dicarboxylamide; 2-nitrofluorenone-5-carboxylic acid; 2,7-dinitrofluorenone-5-carboxylic acid; 2,7-dinitrofluorenone-5-carboxylamide; 2-nitrofluorenone-5,7-dicarboxylic acid; 2,4-dinitrofluorenone-5,7-dicarboxylic acid was studied. The highest activity was demonstrated for 2,7-DNF-5-KA and 2,7-DNF-5,7-DK which induced frameshift mutations in the tester strains Salmonella typhimurium TA1537, TA97, TA1538, TA98. High mutagenicity of these compounds is correlated with the position of nitro-groups and the effects of carboxylic and carboxyamide groups.
研究了联苯和芴酮的7种衍生物的比较诱变活性，包括4,4'-二硝基联苯-2,2'-二羧酸；4,4',6,6'-四硝基联苯-2,2'-二甲酰胺；2-硝基芴酮-5-羧酸；2,7-二硝基芴酮-5-羧酸；2,7-二硝基芴酮-5-甲酰胺；2-硝基芴酮-5,7-二羧酸；2,4-二硝基芴酮-5,7-二羧酸。2,7-二硝基芴酮-5-羧酸（2,7-DNF-5-KA）和2,7-二硝基芴酮-5,7-二羧酸（2,7-DNF-5,7-DK）在鼠伤寒沙门氏菌TA1537、TA97、TA1538、TA98测试菌株中诱导移码突变，表现出最高活性。这些化合物的高诱变性与硝基的位置以及羧基和羧酰胺基的作用相关。
