Banfi G, Marinelli M, Roi G S, Giacometti M
Dipartimento di Medicina di Laboratorio, Istituto Scientifico H San Raffaele, Milano, Italy.
J Clin Lab Anal. 1995;9(1):34-6. doi: 10.1002/jcla.1860090106.
Physical activity could modify platelet count and platelet indices. Previous reports showed modifications after exercise linked to type and duration of sports performances. The shortage of studies in this field stems from the crucial methodological problem of EDTA (ethylenediaminetetraacetic acid)-dependent, mean platelet volume modifications: the published data on platelets count and indices were obtained by using a light-scattering system without standardization of the period elapsed from drawing to measurement. We present a study of platelet indices performed in athletes participating in an "extreme" performance, a race of 30 km in altitude (6,700 m of ascents and descents), using standardized measurement by an aperture-impedance instrument transferred in the field. The platelet count and mean platelet volume significantly increased in athletes, whereas platelet distribution width decreased. The mean initial values were 240.610(9)/L for platelet count, 8.79 fL for mean platelet volume, and 15.79% for platelet distribution width. The correspondent mean final values were 288.410(9)/L, 9.14 fL, and 15.48%. The modifications of platelet count and indices were always in the physiological reference range. The entity and the rapidity of platelet count and indices modifications suggest that the more probable source of variation is the recruitment of noncirculating pools of mature platelets. Strenuous exercise does not show abnormal changes of platelet parameters.
体育活动可能会改变血小板计数和血小板指数。先前的报告显示，运动后的改变与体育表现的类型和持续时间有关。该领域研究的不足源于EDTA（乙二胺四乙酸）依赖性平均血小板体积改变这一关键方法学问题：已发表的关于血小板计数和指数的数据是通过使用光散射系统获得的，且未对采血到测量之间经过的时间进行标准化。我们开展了一项针对参与“极限”表现（一场海拔30公里的比赛，其中有6700米的爬升和下降）的运动员的血小板指数研究，使用在现场转移的孔径阻抗仪进行标准化测量。运动员的血小板计数和平均血小板体积显著增加，而血小板分布宽度降低。血小板计数的平均初始值为240.6×10⁹/L，平均血小板体积为8.79 fL，血小板分布宽度为15.79%。相应的平均最终值分别为288.4×10⁹/L、9.14 fL和15.48%。血小板计数和指数的改变始终处于生理参考范围内。血小板计数和指数改变的程度及速度表明，更可能的变异来源是成熟血小板非循环池的募集。剧烈运动未显示血小板参数的异常变化。
