Wang Z G, Ma X Y, Su Y B, Feng B, Zhang F R, Li Z Q
Institute of Environmental Prevention, Northeast Coal Company, Changchun, P.R. China.
J Environ Pathol Toxicol Oncol. 1994;13(3):205-7.
We studied the effects of nutrients such as vitamin C, E, B6, niacin, and methionine on the blastogenic response of splenocytes and lipid peroxidation (LPO) in lung and liver of mice exposed to SiO2 dust. The results showed that after treatment with SiO2, the blastogenic response of splenocytes decreased significantly (p < 0.001), whereas the LPO level in lung and liver increased remarkably (lung p < 0.05; liver p < 0.001). Vitamin E, C, and niacin strongly enhanced the blastogenic response of T and B splenic lymphocytes to concanavalin-A and to lipopolysaccharide (p < 0.001). The effects of methionine and B6 were much less intense. Other supplied nutrients have been shown to inhibit LPO in lung and liver of mice exposed to SiO2 (p < 0.001).
我们研究了维生素C、E、B6、烟酸和蛋氨酸等营养素对暴露于二氧化硅粉尘的小鼠脾细胞增殖反应以及肺和肝脏脂质过氧化（LPO）的影响。结果表明，用二氧化硅处理后，脾细胞的增殖反应显著降低（p<0.001），而肺和肝脏中的LPO水平显著升高（肺p<0.05；肝脏p<0.001）。维生素E、C和烟酸强烈增强了T和B脾淋巴细胞对刀豆球蛋白A和脂多糖的增殖反应（p<0.001）。蛋氨酸和B6的作用则弱得多。已证明其他提供的营养素可抑制暴露于二氧化硅的小鼠肺和肝脏中的LPO（p<0.001）。
