Ma X Y, Su Y B, Zhang F R, Li J F
School of Public Health, N. Bethune Medical University, P.R. China.
J Environ Pathol Toxicol Oncol. 1996;15(1):51-3.
Semipurified diets containing 30 or 500 ppm of dl-alpha-tocopherol (VE) were fed for 12 weeks to young (3-month-old) and old (20-month-old) Swiss mice. We measured the blastogenic response of splenocytes, the serum VE, and the lipofuscin levels in brains and hearts. We found that old mice fed with 500 ppm VE diet had a significantly higher serum VE level and blastogenic response of splenocytes to concanavalin-A (ConA) and lipopolysaccharide (LPS) than those fed with 30 ppm VE diet (p < 0.01). However, the lipofuscin level in the brains and hearts of aged mice declined substantially with the VE supplementation (heart: p < 0.001, brain: p < 0.05). Furthermore, the effects of dietary VE on the serum VE and tissue lipofuscin content in aged mice were much more obvious than in the young animals.
将含有30 ppm或500 ppm dl-α-生育酚（维生素E）的半纯化日粮喂养年轻（3个月大）和年老（20个月大）的瑞士小鼠12周。我们测量了脾细胞的增殖反应、血清维生素E水平以及大脑和心脏中的脂褐素水平。我们发现，喂食500 ppm维生素E日粮的老年小鼠血清维生素E水平显著高于喂食30 ppm维生素E日粮的小鼠，脾细胞对刀豆球蛋白A（ConA）和脂多糖（LPS）的增殖反应也显著更高（p < 0.01）。然而，补充维生素E后，老年小鼠大脑和心脏中的脂褐素水平大幅下降（心脏：p < 0.001，大脑：p < 0.05）。此外，日粮维生素E对老年小鼠血清维生素E和组织脂褐素含量的影响比对年轻动物的影响更为明显。
