Wang Z G, Ma X Y, Su Y B, Liu M, Zhang F R, Qi H W
Institute of Environmental Prevention, Northeast Coal Company, Changchun, P.R. China.
J Environ Pathol Toxicol Oncol. 1994;13(3):209-12.
We studied the effects of a nutrient supplemented diet on the function of alveolar macrophages of silicosis rats and on the blastogenic response of lymphocytes, glutathione peroxidase (GSH-PX) activity, and lipid peroxidase (LPO) activity in the blood of silicosis patients. The results showed that a nutrient supplemented diet increased the phagocytosis rate (p < 0.01) and index (p < 0.05) of alveolar macrophages of silicosis rats. A nutrient supplemented diet also enhanced significantly the GSH-PX activity (p < 0.001) and the blastogenic response of lymphocytes (p < 0.01), and decreased substantially the LPO content (p < 0.05) in the blood of silicosis patients. We conclude that a nutrient supplemented diet may play an important role in antilipid peroxidation, decreased free radical reaction, stabilizing cell membrane, delaying lung fibrosis, and enhancing immune functions of the body.
我们研究了营养强化饮食对矽肺大鼠肺泡巨噬细胞功能、矽肺患者血液中淋巴细胞的增殖反应、谷胱甘肽过氧化物酶（GSH-PX）活性以及脂质过氧化物酶（LPO）活性的影响。结果表明，营养强化饮食提高了矽肺大鼠肺泡巨噬细胞的吞噬率（p<0.01）和吞噬指数（p<0.05）。营养强化饮食还显著增强了矽肺患者血液中的GSH-PX活性（p<0.001）和淋巴细胞的增殖反应（p<0.01），并大幅降低了LPO含量（p<0.05）。我们得出结论，营养强化饮食可能在抗脂质过氧化、减少自由基反应、稳定细胞膜、延缓肺纤维化以及增强机体免疫功能方面发挥重要作用。
