Liu B L
Shanxi Medical College, Taiyuan.
Zhonghua Yu Fang Yi Xue Za Zhi. 1993 Jan;27(1):10-2.
The changes of oxidant and anti-oxidant system of alveolar macrophage under the influence of quartz were studied from different angles such as in vitro cell test, experimental rat silicosis and patients with silicosis. The results showed that quartz dust could induce the production of oxygen derived free radicals of alveolar macrophages which could lead to lipid peroxidation of cell membrane system. These changes were especially obvious in the early stage of experimental rat silicosis and in the patients with silicosis. The process recycling dust involving ingestion, destruction and re--releasing of the dust by the alveolar macrophages, was an important link in the production and development of lung fibrosis. It also illustrated the role played by oxidative injury of alveolar macrophages in the development of lung fibrosis.
从体外细胞试验、实验性大鼠矽肺和矽肺患者等不同角度，研究了石英影响下肺泡巨噬细胞氧化和抗氧化系统的变化。结果表明，石英粉尘可诱导肺泡巨噬细胞产生氧自由基，导致细胞膜系统脂质过氧化。这些变化在实验性大鼠矽肺早期和矽肺患者中尤为明显。肺泡巨噬细胞对粉尘的摄取、破坏和再释放过程，是肺纤维化发生发展的重要环节。这也说明了肺泡巨噬细胞氧化损伤在肺纤维化发展中的作用。
