Penn O C, Brower R W, Leicher F, Meester G T, Bos E
J Thorac Cardiovasc Surg. 1976 Apr;71(4):526-32.
Myocardial left ventricular contractility is assessed in 8 orthotopic heart-transplanted dogs during chronic rejection by a noninvasive method. The mean circumferential velocity of shortening (Vcf) is calculated from endocardial marker motion on cinefilms. A model for chronic rejection after cardiac transplantation was obtained by histocompatibility matching in DLA identical Beagle littermates. No immunosuppressive treatment was used. All dogs eventually died of chronic rejection; mean survival time was 112.5 days. LV contractility shows the following pattern: Chronic rejection causes an important contractility decrease (P less than 0.001) with two significant drops: (1) from the week preoperative to the first week after transplantation (P less than 0.02) and (2) from week terminal minus one to the terminal week (P less than 0.01). This study describes the technique and the changes in Vcf observed over a period of time in a predictable model.
采用非侵入性方法，对8只慢性排斥反应期的原位心脏移植犬的心肌左心室收缩力进行评估。根据电影胶片上心内膜标记物的运动计算平均圆周缩短速度（Vcf）。通过对同基因比格犬同窝仔犬进行组织相容性匹配，建立心脏移植后慢性排斥反应模型。未使用免疫抑制治疗。所有犬最终均死于慢性排斥反应；平均生存时间为112.5天。左心室收缩力呈现以下模式：慢性排斥反应导致显著的收缩力下降（P<0.001），有两个明显下降阶段：（1）从术前一周到移植后第一周（P<0.02）；（2）从终末期前一周到终末期（P<0.01）。本研究描述了在一个可预测模型中观察到的Vcf技术及一段时间内的变化情况。
