[质子激发X射线发射法对血清和脑脊液微量元素的分析——年龄的影响及帕金森病患者的变化]

[Trace elements analysis of serum and cerebrospinal fluid with PIXE--effect of age and changes in parkinsonian patients].

作者信息

Takahashi S, Takahashi J, Osawa N, Abe T, Yonezawa H, Sera K, Tohgi H

机构信息

Department of Neurology, Iwate Medical University.

出版信息

Nihon Ronen Igakkai Zasshi. 1994 Nov;31(11):865-71. doi: 10.3143/geriatrics.31.865.

DOI:10.3143/geriatrics.31.865

PMID:7723189

Abstract

The concentrations of Br, Cu, Fe, Se, Zn, Mg were determined by particle-induced X-ray emission (PIXE) in serum and cerebrospinal fluid (CSF) of 13 untreated, 7 L-dopa treated parkinsonian patients and 25 controls. There were significant positive correlations between serum concentrations and CSF concentrations of Br, Cu, Fe. The Cu/Zn ratio in the serum and the CSF/serum ratio of Br were significantly increased with age in normal controls. The mean CSF concentration of Mg in both treated and untreated parkinsonian patients was lower than in controls. PIXE is a valuable method for multielemental analysis of the serum and CSF.

摘要

通过粒子诱导X射线发射（PIXE）测定了13例未经治疗的帕金森病患者、7例接受左旋多巴治疗的帕金森病患者以及25名对照者血清和脑脊液（CSF）中的溴（Br）、铜（Cu）、铁（Fe）、硒（Se）、锌（Zn）、镁（Mg）浓度。血清中Br、Cu、Fe的浓度与脑脊液中的浓度之间存在显著正相关。正常对照组中，血清中的铜锌比以及脑脊液与血清中溴的比例均随年龄显著增加。接受治疗和未接受治疗的帕金森病患者脑脊液中镁的平均浓度均低于对照组。PIXE是一种用于血清和脑脊液多元素分析的有价值方法。