Krivtsova M A, Moroshkina E B, Gliben E N
Mol Biol (Mosk). 1995 Jan-Feb;29(1):144-8.
The DNA complexes with actinocyl-bis-bithiazole have been investigated by spectrophotometry, viscometry and flow birefringence. It was estimated, that at low degrees of binding (r < or = 0.07) this compound binds to DNA by bisintercalation via bithiazole groups located in positions 1 and 9 of the phenoxazone chromophore. The phenoxazone moiety plays in this case the role of a link connecting two intercalating fragments. As r increases, external groove binding becomes the second type of complex formation.
通过分光光度法、粘度测定法和流动双折射法对放线菌素双二噻唑与DNA的复合物进行了研究。据估计，在低结合度（r≤0.07）时，该化合物通过位于吩恶嗪发色团1和9位的二噻唑基团以双插入方式与DNA结合。在这种情况下，吩恶嗪部分起到连接两个插入片段的连接作用。随着r的增加，外部沟结合成为第二种复合物形成类型。
