两栖类胚胎中组织决定和模式形成的分子机制。

Molecular mechanisms of tissue determination and pattern formation in amphibian embryos.

作者信息

Tiedemann H, Tiedemann H, Grunz H, Knöchel W

机构信息

Institut für Molekularbiologie und Biochemie, Freien Universität, Berlin.

出版信息

Naturwissenschaften. 1995 Mar;82(3):123-34. doi: 10.1007/BF01177272.

DOI:10.1007/BF01177272

PMID:7723850

Abstract

Factors of the TGF-beta superfamily (activin, vegetalizing factor) and the FGF family determine endoderm and mesoderm. The dorsoventral polarity of the mesoderm depends on additional factors (BMP-4, Wnt-8, noggin). Activin can directly activate gene transcription by signal transduction. Mesoderm is determined by factors prelocalized in the marginal zone. Its differentiation depends also on the animal ectoderm. Neural inducing factors have been partially purified. A masked neuralizing factor in the ectoderm is activated by induction of the ectoderm to the nervous system. Phorbolester can evoke neuralization signaling.

摘要

转化生长因子-β超家族（激活素、植物化因子）和FGF家族的因子决定内胚层和中胚层。中胚层的背腹极性取决于其他因子（骨形态发生蛋白-4、Wnt-8、头蛋白）。激活素可通过信号转导直接激活基因转录。中胚层由边缘区预先定位的因子决定。其分化也取决于动物外胚层。神经诱导因子已被部分纯化。外胚层中一种被掩盖的神经化因子通过外胚层向神经系统的诱导而被激活。佛波酯可引发神经化信号。