Pierrefiche O, Champagnat J, Richter D W
II. Physiologisches Institut, Universität Göttingen, Germany.
Neurosci Lett. 1995 Jan 23;184(2):101-4. doi: 10.1016/0304-3940(94)11179-m.
Intracellular injection of the calcium chelator BAPTA into postinspiratory (PI) and late inspiratory neurones (late-I) of the ventral respiratory group of anaesthetised cat was performed to study the role of intracellular free calcium in patterning the activity of neurones controlling termination of inspiration. BAPTA injection into neurones resulted in an increase of input resistance and prolongation of action potential discharge with reduced adaptation. In addition, late-I neurones developed a secondary burst of action potentials during the postinspiratory phase of the cycle. We conclude that intracellular free calcium controls (1) the duration of activation and the degree of adaptation of PI neurones and (2) repolarisation of late-I neurones during postinspiration.
将钙螯合剂BAPTA细胞内注射到麻醉猫腹侧呼吸组的吸气后（PI）和吸气后期神经元（晚期I）中，以研究细胞内游离钙在控制吸气终止的神经元活动模式形成中的作用。向神经元注射BAPTA导致输入电阻增加，动作电位发放延长且适应性降低。此外，晚期I神经元在周期的吸气后阶段出现了动作电位的二次爆发。我们得出结论，细胞内游离钙控制（1）PI神经元的激活持续时间和适应程度，以及（2）吸气后期晚期I神经元的复极化。
