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阿尔茨海默型老年痴呆症中穿通通路和齿状回通路的海马内路径退化。

Degeneration of the intrahippocampal routes of the perforant and alvear pathways in senile dementia of Alzheimer type.

作者信息

Mizutani T, Kashara M

机构信息

Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Japan.

出版信息

Neurosci Lett. 1995 Jan 23;184(2):141-4. doi: 10.1016/0304-3940(94)11190-t.

DOI:10.1016/0304-3940(94)11190-t
PMID:7724049
Abstract

In five autopsied brains with senile dementia of Alzheimer type, the intrahippocampal routes of the perforant and alvear pathways were demonstrated by assessment of the distribution of isomorphic gliosis. Our results suggest that the perforant pathway goes along the stratum lacunosum-moleculare of the hippocampus proper to end in the dentate gyrus after perforating the prosubiculum but does not traverse the hippocampal sulcus, and that the alvear pathway enters into the stratum oriens of the hippocampus proper and the alveus from the white matter ventral to the subiculum.

摘要

在5例阿尔茨海默型老年性痴呆患者的尸检大脑中,通过评估同构性胶质增生的分布,显示了穿通通路和齿状通路的海马内走行。我们的结果表明,穿通通路沿着海马本部的腔隙-分子层走行,在穿过前下托后终止于齿状回,但不穿过海马沟;齿状通路从下托腹侧的白质进入海马本部的原层和齿状回。

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