Frésard A, Vindimian M, Genin C, Le Petit J C, Pozzetto B, Lucht F
Service des Maladies Infectieuses et Tropicales, Hôpital Bellevue, CHU, ST-Etienne, France.
Pathol Biol (Paris). 1994 Oct;42(8):750-3.
Except for Ig E, serum immunoglobulin abnormalities in persons with human immunodeficiency virus (HIV) infection have been well described. Serum IgE levels have been shown to rise with progressive disease. The authors evaluated IgE in 148 HIV-seropositive individuals with or without acquired immunodeficiency syndrome (AIDS). Mean serum IgE levels were compared between groups based on absolute CD4 lymphocyte counts or clinical status (CDC) and with a seronegative control group. Higher serum IgE levels were observed in seropositive-patients. A rise in IgE serum is common in patients with HIV infection; it could be link with an earlier dysregulation in the IgE synthesis. No correlation was found between IgE level and CD4 counts.
除IgE外，人类免疫缺陷病毒（HIV）感染者血清免疫球蛋白异常已有详尽描述。血清IgE水平已显示会随疾病进展而升高。作者评估了148名有或无获得性免疫缺陷综合征（AIDS）的HIV血清阳性个体的IgE情况。根据绝对CD4淋巴细胞计数或临床状态（疾病控制与预防中心）将这些个体分组，并与血清阴性对照组比较平均血清IgE水平。血清阳性患者中观察到较高的血清IgE水平。HIV感染患者中IgE血清升高很常见；这可能与IgE合成早期失调有关。未发现IgE水平与CD4计数之间存在相关性。
