Lieb L E, Mundy T M, Goldfinger D, Pepkowitz S H, Brunell P A, Caldwell M B, Ward J W
Los Angeles County Department of Health Services, CA 90005, USA.
Pediatrics. 1995 May;95(5):717-21.
To retrospectively identify unrecognized human immunodeficiency virus type 1 (HIV-1) infection among a cohort of children transfused as neonates before donated blood was routinely screened for HIV-1 antibody.
Records at a large, private, metropolitan hospital were reviewed to identify children who were transfused as neonates between January 1980 and March 1985 and discharged alive from the hospital. Multiple data sources were used to locate these children. Parents or guardians were contacted, and their children were offered HIV-1 antibody testing and physical examination.
Of the 775 children identified as having received transfusions during the project period, 644 (83%) were located, and 443 (69%) were evaluated for HIV-1 infection. Among those evaluated, 33 (7%) had antibody to HIV-1, including 14 whose infections had not been previously diagnosed. At the time of enrollment, 13 children infected with HIV-1 were asymptomatic an average of 63 months after transfusion.
HIV-1 antibody testing should be considered for all children, regardless of clinical status, who were transfused before routine blood donor screening was implemented in March 1985, particularly in areas with a high incidence of acquired immunodeficiency syndrome during those years.
回顾性确定在对献血者常规筛查人类免疫缺陷病毒1型（HIV-1）抗体之前接受新生儿输血的一组儿童中未被识别的HIV-1感染情况。
查阅一家大型私立都市医院的记录，以确定1980年1月至1985年3月期间接受新生儿输血并存活出院的儿童。使用多个数据源来查找这些儿童。联系了父母或监护人，并为他们的孩子提供了HIV-1抗体检测和体格检查。
在确定为在项目期间接受输血的775名儿童中，找到了644名（83%），并对443名（69%）进行了HIV-1感染评估。在接受评估的儿童中，33名（7%）有HIV-1抗体，其中14名的感染此前未被诊断。在入组时，13名感染HIV-1的儿童在输血后平均63个月无症状。
对于1985年3月实施常规献血者筛查之前接受输血的所有儿童，无论其临床状况如何，都应考虑进行HIV-1抗体检测，特别是在那些年获得性免疫缺陷综合征发病率较高的地区。
