Fagan E A, Singer M
Department of Medicine, University College of London Medical School, UK.
Postgrad Med J. 1995 Feb;71(832):71-8. doi: 10.1136/pgmj.71.832.71.
The pathophysiological effects of severe sepsis, septic shock and related syndromes result from tissues damaged by the uncontrolled production of the mediators of inflammation. Early deaths are related primarily to the acute effects of the systemic inflammatory response. Later deaths are related more closely to the consequences of multiple organ dysfunction. Monoclonal antibodies and other immunotherapies have been developed against bacterial products, cytokines and other mediators involved in this systemic inflammatory response. Immunotherapies may improve outcome in the critically ill with sepsis if used early and as part of the therapeutic regimen of antimicrobial agents and intensive care support.
严重脓毒症、脓毒性休克及相关综合征的病理生理效应源于炎症介质失控产生所导致的组织损伤。早期死亡主要与全身炎症反应的急性效应有关。后期死亡则更紧密地与多器官功能障碍的后果相关。已经研发出针对参与这种全身炎症反应的细菌产物、细胞因子及其他介质的单克隆抗体和其他免疫疗法。如果早期使用免疫疗法，并将其作为抗菌药物治疗方案和重症监护支持的一部分，那么免疫疗法可能会改善脓毒症重症患者的预后。
