Bakalli R I, Pesti G M, Ragland W L, Konjufca V
Department of Poultry Science, University of Georgia, Athens 30602-2772, USA.
Poult Sci. 1995 Feb;74(2):360-5. doi: 10.3382/ps.0740360.
Male commercial broiler strain chickens were fed from hatching to 42 d of age either a control diet (based on corn and soybean meal) or the control diet supplemented with 250 mg copper/kg diet from cupric sulfate pentahydrate (for 35 or 42 d). Hypocholesterolemia (11.8% reduction) and decreased breast muscle cholesterol (20.4% reduction) were observed in copper-supplemented birds. There was a slight increase (P > .05) in breast muscle copper (14.5%), and all levels were very low (< .5 mg/kg). Feeding copper for 42 vs 35 d resulted in lower levels of cholesterol in the plasma (12.9 vs 10.8% reduction) and breast muscle (24.6 vs 16.2% reduction). Very similar results were found in two additional experiments in which hypocholesterolemia and reduced breast muscle cholesterol were associated with reduced plasma triglycerides and blood reduced glutathione. It is well known that hypercholesterolemia is a symptom of dietary copper deficiency. The data presented here indicate that blood and breast muscle cholesterol are inversely related to dietary copper in excess of the dietary requirement for maximal growth. The cholesterol content of the edible muscle tissue of broiler chickens can be reduced by approximately 25% after feeding a supranormal level of copper for 42 d without altering the growth of the chickens or substantially increasing the copper content of the edible meat.
雄性商品肉鸡从孵化到42日龄，分别饲喂对照日粮（以玉米和豆粕为基础）或添加了250毫克/千克硫酸铜的对照日粮（添加35天或42天）。在添加铜的鸡中观察到了低胆固醇血症（降低11.8%）和胸肌胆固醇降低（降低20.4%）。胸肌铜含量略有增加（P>.05）（增加14.5%），且所有水平都非常低（<.5毫克/千克）。饲喂42天铜与饲喂35天铜相比，血浆胆固醇水平更低（分别降低12.9%和10.8%），胸肌胆固醇水平也更低（分别降低24.6%和16.2%）。在另外两个实验中发现了非常相似的结果，即低胆固醇血症和胸肌胆固醇降低与血浆甘油三酯降低和血液还原型谷胱甘肽降低有关。众所周知，高胆固醇血症是膳食铜缺乏的症状。此处给出的数据表明，血液和胸肌胆固醇与超过最大生长所需膳食铜量的膳食铜呈负相关。在饲喂超正常水平的铜42天后，肉鸡可食用肌肉组织中的胆固醇含量可降低约25%，而不会改变鸡的生长或大幅增加可食用肉中的铜含量。
