Claudel J P, Ninet J, Coppéré B
Service de soins intensifs cardiologiques, Hôpital cardiologique Louis-Pradel, Lyon.
Rev Prat. 1995 Jan 1;45(1):56-61.
An atheromatous aorta may be the source of micro-emboli composed of cholesterol crystals. These cholesterol emboli presumably result from dislodgment of atheromatous material occurring either spontaneously, or consecutively to a coronary angiography, an aortic surgery or even an anticoagulant or thrombolytic treatment. Even if the best known clinical feature is the "blue toe" syndrome together with renal insufficiency, the spectrum of disease caused by cholesterol emboli ranges from asymptomatic to rapidly progressive multiple system failure. Therefore cholesterol embolism is a serious complication of aortic atherosclerosis and often holds a poor prognosis. Diagnosis is confirmed by skin or muscle biopsy and fundoscopic examination. The optimal treatment remains to be established.
动脉粥样硬化的主动脉可能是由胆固醇结晶构成的微栓子的来源。这些胆固醇栓子可能源于动脉粥样硬化物质的脱落，其发生可能是自发的，或是在冠状动脉造影、主动脉手术后，甚至是在抗凝或溶栓治疗之后。即使最广为人知的临床特征是“蓝趾”综合征伴肾功能不全，但胆固醇栓子所致疾病的范围从无症状到快速进展的多系统衰竭。因此，胆固醇栓塞是主动脉动脉粥样硬化的严重并发症，且预后往往不佳。通过皮肤或肌肉活检以及眼底镜检查可确诊。最佳治疗方案仍有待确定。
