Lissens P, Michiels H, Geysens P, Van de Voorde W, Lauweryns J
Departement of Urology, Heilig Hart Hospital, Leuven, Belgium.
Acta Urol Belg. 1995 Mar;63(1):109-12.
In this report a case of bilateral papillary cystadenoma of the epididymis is described, a tumor associated with the Von Hippel-Lindau's disease (cerebelloretinal hemangioblastomatosis). Reports about the Von Hippel-Lindau's disease do only infrequently mention epididymal adenomas because the latter is mostly not associated with any symptoms. Retinal angiomatosis, cerebellar hemagioblastoma, pheochromocytoma and renal cell carcinoma are the lesions in the Von Hippel-Lindau's disease which cause symptoms and as a consequence disease. Because of some histological similarities between papillary cystadenoma and the clear cell type of renal adenocarcinoma a metastasis of a renal cell carcinoma has to be added to the list of differential diagnosis in case of an epididymal benign tumor apart from adenomatoid tumor, fibroma, lipoma,... The epididymal papillary cystadenoma, which is the only known benign epididymal tumor of epithelial origin, is considered a hereditary hamartoma. The precise histogenetic origin is still controversial.
在本报告中，描述了一例双侧附睾乳头状囊腺瘤病例，该肿瘤与冯·希佩尔-林道病（小脑视网膜血管瘤病）相关。关于冯·希佩尔-林道病的报告很少提及附睾腺瘤，因为后者大多不伴有任何症状。视网膜血管瘤病、小脑成血管细胞瘤、嗜铬细胞瘤和肾细胞癌是冯·希佩尔-林道病中引起症状并导致疾病的病变。由于乳头状囊腺瘤与肾腺癌透明细胞型之间存在一些组织学相似性，除腺瘤样肿瘤、纤维瘤、脂肪瘤等外，在附睾良性肿瘤的鉴别诊断清单中还必须增加肾细胞癌转移的情况。附睾乳头状囊腺瘤是唯一已知的上皮起源的附睾良性肿瘤，被认为是一种遗传性错构瘤。其确切的组织发生起源仍存在争议。
