对比剂剂量、成像时间和病变大小对脑内转移瘤磁共振检测的影响。

The effect of contrast dose, imaging time, and lesion size in the MR detection of intracerebral metastasis.

作者信息

Yuh W T, Tali E T, Nguyen H D, Simonson T M, Mayr N A, Fisher D J

机构信息

Department of Radiology, University of Iowa College of Medicine, Iowa City, USA.

出版信息

AJNR Am J Neuroradiol. 1995 Feb;16(2):373-80.

PMID:7726087

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8338330/

Abstract

PURPOSE

To evaluate the effect of MR contrast dose versus delayed imaging time on the detection of metastatic brain lesions based on lesion size.

METHODS

Contrast MR examinations with gadoteridol were obtained in 45 patients with brain metastases. The patients were divided into two groups: 16 received cumulative standard dose (0.1 mmol/kg) and 29 received cumulative triple dose (0.3 mmol/kg). Both groups were evaluated at two dose levels (lower dose and higher dose) with two separate injections. Each patient received an initial bolus injection of either 0.05 (cumulative standard dose) or 0.1 (cumulative triple dose) mmol/kg of gadoteridol to reach the lower-dose level and underwent imaging immediately and 10 and 20 minutes later. Thirty minutes after injection, an additional bolus injection of 0.05 (cumulative standard dose) or 0.2 (cumulative triple dose) mmol/kg was administered to reach the cumulative higher-dose level (cumulative standard dose, 0.1 mmol/kg; cumulative triple dose, 0.3 mmol). Images were acquired immediately.

RESULTS

There was no difference in the detection rate for lesions larger than 10 mm among T2-weighted, lower-dose immediate and delayed, or immediate higher-dose images in both study groups. Lesions smaller than 10 mm had improved detection with delayed imaging in both study groups; however, the immediate higher-dose studies still had the highest detection rate.

CONCLUSION

In the evaluation of small central nervous system metastases, either delayed imaging after the injection of standard contrast dose or higher contrast dose may improve their detection, and therefore affect clinical management. Higher contrast dose (cumulative triple dose) studies appear to be more effective than delayed imaging with standard dose.

摘要

目的

基于病变大小评估磁共振对比剂剂量与延迟成像时间对脑转移瘤检测的影响。

方法

对45例脑转移瘤患者进行钆特醇增强磁共振检查。患者分为两组：16例接受累积标准剂量（0.1 mmol/kg），29例接受累积三倍剂量（0.3 mmol/kg）。两组均在两个剂量水平（低剂量和高剂量）进行两次单独注射评估。每位患者先静脉注射0.05（累积标准剂量）或0.1（累积三倍剂量）mmol/kg钆特醇达到低剂量水平，然后立即、10分钟和20分钟后进行成像。注射30分钟后，再静脉注射0.05（累积标准剂量）或0.2（累积三倍剂量）mmol/kg达到累积高剂量水平（累积标准剂量0.1 mmol/kg；累积三倍剂量0.3 mmol），并立即采集图像。