Bhadelia R A, Bogdan A R, Wolpert S M
Department of Radiology, New England Medical Center Hospitals, Boston, Mass 02111, USA.
AJNR Am J Neuroradiol. 1995 Feb;16(2):389-400.
To analyze the characteristics of normal cerebrospinal fluid (CSF) flow waveforms and to relate them to the arterial input and venous output flow waveforms in healthy volunteers.
Cine phase-contrast MR was obtained in 17 volunteers. The temporal velocity information from the cervical pericord CSF spaces, basal cisterns, and aqueduct, as well as the internal carotid and vertebral arteries and internal jugular veins, were plotted as waveforms. The waveforms were analyzed for configurations, amplitudes, and temporal patterns. In four volunteers the reproducibility of the precord CSF flow waveforms was examined on different days. In three volunteers the effect of jugular venous compression on the precord and aqueductal CSF flow waveforms was also evaluated.
(a) Distinct and reproducible configurational features were observed in the CSF flow waveforms. Jugular venous compression produced elevation of the disatolic slope of the precord waveforms. (b) The amplitudes were variable. Jugular venous compression reduced the precord CSF velocities. (c) The systolic temporal parameters were less variable and more reproducible than the diastolic temporal parameters. Jugular venous compression resulted in delay in the systolic parameters of the precord waveforms. (d) Craniocaudal and caudocranial postcord CSF flow occurred either simultaneous with or earlier than the precord CSF flow. Pericord CSF flow in either direction preceded that in the cisterns and in the aqueduct. (e) A significant temporal relationship was noted in the precord space between the time of the R wave to the maximum velocities and the arterial flow.
CSF flow waveform analysis seems to be a reliable, reproducible, and sensitive method for assessing the CSF dynamics.
分析正常脑脊液（CSF）流动波形的特征，并将其与健康志愿者的动脉输入和静脉输出流动波形相关联。
对17名志愿者进行电影相位对比磁共振成像。将来自颈髓周围CSF间隙、脑基底池和导水管以及颈内动脉、椎动脉和颈内静脉的时间速度信息绘制成波形。对波形的形态、幅度和时间模式进行分析。在4名志愿者中，在不同日期检查了脊髓周围CSF流动波形的可重复性。在3名志愿者中，还评估了颈静脉压迫对脊髓周围和导水管CSF流动波形的影响。
（a）在CSF流动波形中观察到明显且可重复的形态特征。颈静脉压迫导致脊髓周围波形舒张期斜率升高。（b）幅度各不相同。颈静脉压迫降低了脊髓周围CSF速度。（c）收缩期时间参数比舒张期时间参数变异性小且更具可重复性。颈静脉压迫导致脊髓周围波形收缩期参数延迟。（d）颅尾和尾颅脊髓后CSF流动与脊髓前CSF流动同时或早于脊髓前CSF流动发生。任一方向的脊髓周围CSF流动先于脑池和导水管中的流动。（e）在脊髓前间隙中，从R波到最大速度的时间与动脉血流之间存在显著的时间关系。
CSF流动波形分析似乎是一种评估CSF动力学的可靠、可重复且敏感的方法。
