软组织肉瘤的肝转移
Hepatic metastases from soft-tissue sarcoma.
作者信息
Jaques D P, Coit D G, Casper E S, Brennan M F
机构信息
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
出版信息
Ann Surg. 1995 Apr;221(4):392-7. doi: 10.1097/00000658-199504000-00010.
OBJECTIVE
Hepatic metastases from soft-tissue sarcoma are evaluated to define treatment and its limitations.
METHODS
From 981 adult patients with diagnoses of soft-tissue sarcoma, 65 patients with hepatic metastases were studied.
RESULTS
An intra-abdominal primary site was present in 61 of 65 patients, with 85% high-grade leiomyosarcoma. Hepatic resection was performed in 14 patients (22%). All patients have had recurrences after hepatic resection-11 of 14 in the liver--with a median survival of 30 months. Chemotherapy resulted in partial response in three patients and no complete responses. Survival is not influenced by grade, type, primary site, disease-free interval, chemotherapy, or hepatic resection.
CONCLUSIONS
The uncommon response to conventional chemotherapy does not support its use in the treatment of hepatic metastases from soft-tissue sarcoma. Extent of disease limits the application and success of hepatic resection for soft-tissue sarcoma, and anything less than complete resection is not indicated.
目的
评估软组织肉瘤肝转移的治疗方法及其局限性。
方法
在981例诊断为软组织肉瘤的成年患者中，对65例发生肝转移的患者进行了研究。
结果
65例患者中有61例的原发部位在腹腔内，其中85%为高级别平滑肌肉瘤。14例患者（22%）接受了肝切除术。所有患者在肝切除术后均出现复发，14例中有11例复发于肝脏，中位生存期为30个月。化疗使3例患者部分缓解，无完全缓解病例。生存率不受肿瘤分级、类型、原发部位、无病间期、化疗或肝切除术的影响。
结论
对传统化疗反应不佳，不支持将其用于治疗软组织肉瘤肝转移。疾病范围限制了软组织肉瘤肝切除术的应用和成功率，不完全切除不可取。
Zotero 插件