利福平、氯法齐明和B1912对已建立的小鼠足垫感染中麻风分枝杆菌生存能力的影响。

Effect of rifampin, clofazimine, and B1912 on the viability of Mycobacterium leprae in established mouse footpad infection.

作者信息

Holmes I B, Banerjee D K, Hilson G R

出版信息

Proc Soc Exp Biol Med. 1976 Apr;151(4):637-41. doi: 10.3181/00379727-151-39276.

Abstract

Continuous dietary administration of rifampin to mice with an established Mycobacterium leprae footpad infection reduced the bacillary solid ratio, with an estimated survival half-life of 5-6 days. In rifampin-treated immunosuppressed animals the survival half-life of solid bacilli, in the absence of host immunity, was 12-13 days. Clofazimine and B1912 produced a significant effect on solid ratio only after a lag period of apparently 100 days. The rate of action was considerably slower than that of rifampin. Intermittent (once monthly) administration of both drugs produced effects similar to those of continuous administration.

摘要

对已建立麻风分枝杆菌足垫感染的小鼠持续进行饮食性利福平给药，可降低菌块比例，估计存活半衰期为5 - 6天。在利福平治疗的免疫抑制动物中，在没有宿主免疫的情况下，菌块的存活半衰期为12 - 13天。氯法齐明和B1912仅在明显长达100天的滞后期后才对菌块比例产生显著影响。其作用速度比利福平慢得多。两种药物间歇性（每月一次）给药产生的效果与持续给药相似。