Lyytikäinen O, Saxén H, Ryhänen R, Vaara M, Vuopio-Varkila J
Second Department of Medicine, Helsinki University Central Hospital, Finland.
Clin Infect Dis. 1995 Jan;20(1):24-9. doi: 10.1093/clinids/20.1.24.
A cluster of cases of Staphylococcus epidermidis bacteremia in a neonatal intensive-care unit (NICU) during 1991 raised the question of whether these infections were caused by a single strain. Sixty-seven isolates of S. epidermidis from blood cultures of 56 neonates treated in the NICU between 1986 and 1992 and 54 control strains from other patients with bacteremia were characterized by three typing methods: antibiogram, plasmid profile, and ribotype. Plasmid profiles and ribotype patterns indicated that 11 (16%) of the 67 episodes of S. epidermidis bacteremia in the NICU were caused by a single strain. Although this epidemic strain did not account entirely for the increase in the incidence of bacteremia in the NICU, it did persist for 4 years during the study period. Other clones responsible for smaller outbreaks were also found. These results suggest that S. epidermidis cross-infections are very common in the NICU setting.
1991年，一家新生儿重症监护病房（NICU）出现了一批表皮葡萄球菌菌血症病例，这引发了一个问题，即这些感染是否由单一菌株引起。采用三种分型方法对1986年至1992年间在该NICU接受治疗的56名新生儿血培养中的67株表皮葡萄球菌分离株以及来自其他菌血症患者的54株对照菌株进行了鉴定：抗菌谱、质粒图谱和核糖型。质粒图谱和核糖型模式表明，NICU中67例表皮葡萄球菌菌血症中有11例（16%）是由单一菌株引起的。尽管这种流行菌株并未完全导致NICU中菌血症发病率的上升，但在研究期间它确实持续存在了4年。还发现了其他导致小规模暴发的克隆菌株。这些结果表明，表皮葡萄球菌交叉感染在NICU环境中非常常见。
