新生儿重症监护病房患者表皮葡萄球菌血培养分离株的分子流行病学

Molecular epidemiology of Staphylococcus epidermidis blood isolates from neonatal intensive care unit patients.

作者信息

Nesin M, Projan S J, Kreiswirth B, Bolt Y, Novick R P

机构信息

Perinatology Center, Cornell University Medical Center, New York 10021, USA.

出版信息

J Hosp Infect. 1995 Oct;31(2):111-21. doi: 10.1016/0195-6701(95)90166-3.

DOI:10.1016/0195-6701(95)90166-3

PMID:8551017

Abstract

Twelve episodes of Staphylococcus epidermidis bacteraemia occurred within three months in a neonatal intensive care unit. Plasmid profiles and Southern blot hybridization with five different probes were used to determine whether an endemic strain of S. epidermidis could be identified among the contemporary isolates. It was concluded that this methodology was satisfactory for differentiation between isolates of coagulase-negative staphylococci: fifteen isolates were divided in eight groups indicating that there was no single endemic strain causing the outbreak.

摘要

在一家新生儿重症监护病房内，三个月内发生了12例表皮葡萄球菌菌血症。运用质粒图谱分析以及与五种不同探针进行Southern印迹杂交，以确定在同时期分离出的菌株中是否能识别出表皮葡萄球菌的流行菌株。得出的结论是，该方法对于区分凝固酶阴性葡萄球菌的分离株是令人满意的：15株分离株被分为八组，这表明不存在单一的流行菌株导致此次暴发。