Goldberg G S, Bertram J S
Molecular Oncology Unit, University of Hawaii at Manoa, Honolulu 96813, USA.
In Vivo. 1994 Nov-Dec;8(5):745-54.
There is increasing evidence that gap junctional communication plays an important role in the control of morphogenesis, differentiation and growth. Here we review the genetic diversity of connexins, structural proteins which form the gap junction, with emphasis on their tissue specific expression and present evidence that junctional communication is perturbed during the process of carcinogenesis. Finally we discuss the clinical implications of these findings in the light of recent experiments demonstrating that increased junctional communication, achieved by pharmacological or by molecular means, results in suppression of tumorigenicity or in enhanced growth control.
越来越多的证据表明，间隙连接通讯在形态发生、分化和生长的控制中起着重要作用。在此，我们综述了构成间隙连接的结构蛋白——连接蛋白的遗传多样性，重点关注其组织特异性表达，并提供证据表明在癌变过程中间隙连接通讯受到干扰。最后，鉴于最近的实验表明，通过药理学或分子手段实现的间隙连接通讯增加会导致肿瘤发生的抑制或生长控制的增强，我们讨论了这些发现的临床意义。
