Krutovskikh V, Yamasaki H
Unit of Multistage Carcinogenesis, International Agency for Research on Cancer, Lyon, France.
Histol Histopathol. 1997 Jul;12(3):761-8.
There is a growing body of evidence supporting the etiologic implication of gap junctional intercellular communication disorders in carcinogenesis. Substantial progress has recently been made both in molecular biology of gap junction and in the field of cancer research. They provide new insights and conceptions of gap junctional disorders in tumor pathology. Modern understanding of the structure, function and regulation of gap junctions, as well as putative mechanisms of its disorders in human and experimental carcinogenesis are discussed in this review with particular emphasis on fast-moving aspects of this problem.
越来越多的证据支持间隙连接细胞间通讯障碍在致癌过程中的病因学意义。最近在间隙连接的分子生物学和癌症研究领域都取得了实质性进展。它们为肿瘤病理学中间隙连接障碍提供了新的见解和概念。本综述讨论了对间隙连接的结构、功能和调节以及其在人类和实验性致癌过程中障碍的推定机制的现代理解，特别强调了这个问题的快速发展方面。
