一种逆转录病毒疾病的宿主范围控制：弗瑞德氏红白血病
Host-range control of a retroviral disease: Friend erythroleukemia.
作者信息
Hoatlin M E, Kabat D
机构信息
Divn of Hematology and Medical Oncology, Oregon Health Sciences University, Portland 97201-3098, USA.
出版信息
Trends Microbiol. 1995 Feb;3(2):51-7. doi: 10.1016/s0966-842x(00)88875-7.
PMID:7728385
Abstract
Since its discovery in 1957, Friend viral erythroleukemia has been the major model for understanding host genetic barriers to retroviral diseases and has facilitated the discovery of many polymorphic leukemia-control genes of mice. Some of these genes limit helper-virus replication, target-cell (erythroblast) pools or immune responses. At least one host gene appears to block the viral oncoprotein.
摘要
自1957年发现以来，弗瑞德病毒诱发的红细胞白血病一直是理解宿主对逆转录病毒疾病遗传屏障的主要模型，并推动了许多小鼠多态性白血病控制基因的发现。其中一些基因限制辅助病毒复制、靶细胞（成红细胞）库或免疫反应。至少有一个宿主基因似乎会阻断病毒癌蛋白。
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