Bianchi A
Department of Neonatal and Paediatric Surgery, Royal Manchester Children's Hospital, Pendlebury, England.
Semin Pediatr Surg. 1995 Feb;4(1):54-9.
The patient with short bowel syndrome is essentially unable to absorb sufficient nutrients. This is caused by either short mucosal contact time, insufficient mucosal surface area (enterocyte mass), or a combination of the two. Management consists primarily in sustaining health and growth by intravenous nutrition and in enhancing the natural intestinal adaptation response. Surgery in the form of autologous gastrointestinal reconstruction (AGIR) is designed to redistribute the patient's own residual absorptive bowel to enhance adaptation and, possibly, to increase the absorptive mucosal surface by neomucosal growth. The alternative and ultimate fallback procedure in the management of intestinal failure is bowel transplantation, with its associated serious immunosuppression-related complications. Imaginative AGIR techniques provide new hope for the future.
短肠综合征患者基本上无法吸收足够的营养。这是由于黏膜接触时间过短、黏膜表面积（肠上皮细胞量）不足，或两者兼而有之。治疗主要包括通过静脉营养维持健康和生长，以及增强肠道的自然适应性反应。自体胃肠重建（AGIR）形式的手术旨在重新分配患者自身残留的具有吸收功能的肠段，以增强适应性，并可能通过新黏膜生长增加吸收性黏膜表面积。肠道衰竭管理中的替代和最终补救方法是肠道移植，这伴有与严重免疫抑制相关的并发症。富有想象力的AGIR技术为未来带来了新希望。
