Dubovi E J
Diagnostic Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York.
Vet Clin North Am Food Anim Pract. 1994 Nov;10(3):503-14. doi: 10.1016/s0749-0720(15)30535-1.
The major economic impact of BVDV infections is in producing reproductive dysfunctions. The virus can have a detrimental impact on the developing fetus at all stages, but the most severe consequences occur early in gestation. The virus is maintained in the bovine population through the production of PI offspring. Only the NCB biotype of the virus can produce PI calves. The NCB biotypes is the one that produces the vast majority of BVDV infections and, as a consequence, the greatest economic losses. Biotype and antigenic variation are two independent variables and vaccines should emphasise antigenic composition, not biotype. A BVDV control program that does not emphasize heifers is doomed to failure.
牛病毒性腹泻病毒（BVDV）感染的主要经济影响在于引发繁殖功能障碍。该病毒在胎儿发育的各个阶段都可能产生有害影响，但最严重的后果发生在妊娠早期。通过持续性感染（PI）后代的产生，病毒在牛群中得以持续存在。只有该病毒的非细胞病变生物型（NCB）能产生PI犊牛。NCB生物型引发了绝大多数的BVDV感染，因此造成了最大的经济损失。生物型和抗原变异是两个独立变量，疫苗应着重于抗原组成，而非生物型。一个不重视小母牛的BVDV防控计划注定会失败。
