Pivnick E K, Kerr N C, Kaufman R A, Jones D P, Chesney R W
Department of Pediatrics, University of Tennessee, Memphis 38105, USA.
Clin Pediatr (Phila). 1995 Feb;34(2):73-8. doi: 10.1177/000992289503400202.
Two infants presented with growth failure and were found to have generalized osteomalacia (rickets) due to phosphate depletion from prolonged administration of an aluminum-containing antacid given for the symptoms of colic. One of the infants developed bilateral proptosis due to craniosynostosis related to the underlying metabolic bone disease. The chronic use of aluminum-containing antacids in infants has potential risk for the growing skeleton and is not innocuous. Therefore, antacid therapy should be used in low doses and very cautiously, with routine monitoring of serum calcium and phosphorus in children taking medications which reduce gastrointestinal phosphate absorption.
两名婴儿出现生长发育迟缓，经检查发现因长期服用含铝抗酸剂治疗腹绞痛症状导致磷酸盐耗竭，进而出现全身性骨软化症（佝偻病）。其中一名婴儿因潜在的代谢性骨病相关的颅缝早闭而出现双侧眼球突出。婴儿长期使用含铝抗酸剂对正在生长的骨骼有潜在风险，并非无害。因此，应低剂量且非常谨慎地使用抗酸剂治疗，对服用会减少胃肠道磷酸盐吸收药物的儿童要常规监测血清钙和磷。
