Sakaki N, Momma K, Yamada Y, Egawa N, Ishiwata J
Department of Endoscopy, Tokyo Metropolitan Komagome Hospital, Japan.
Dig Dis Sci. 1995 May;40(5):1087-92. doi: 10.1007/BF02064204.
A two-year endoscopic follow-up study of 45 gastric ulcer patients was conducted in order to ascertain the relationship between Helicobacter pylori infection, the transformation of ulcer scar patterns, and ulcer relapse during maintenance therapy. Endoscopic findings of gastric ulcer scar patterns, which established the quality of ulcer scars, were classified as follows: Sa, with a central depression, Sb, with a coarse regenerating mucosal pattern up to the center, and Sc, with a fine pattern. The proportion of ulcer relapses was 62% among 29 H. pylori-positive patients and 0% among 16 H. pylori-negative patients. In regard to the relationship between H. pylori infection and scar patterns, 94% of the H. pylori-negative patients displayed Sc scar patterns, while all the H. pylori-positive patients showed various scar patterns, ie, Sa in 38%, Sb in 28%, and Sc in 10%. Ulcer relapses in the H. pylori-positive cases were limited to the Sa and Sb groups (100% and 88%, respectively). In conclusion, our results indicate that H. pylori infection plays an important role in the transformation of the ulcer scar patterns which relate to ulcer relapse.
为了确定幽门螺杆菌感染、溃疡瘢痕模式的转变以及维持治疗期间溃疡复发之间的关系，对45例胃溃疡患者进行了为期两年的内镜随访研究。确定溃疡瘢痕质量的胃溃疡瘢痕模式的内镜检查结果分类如下：Sa型，中央凹陷；Sb型，中央有粗糙的再生黏膜模式；Sc型，有精细模式。29例幽门螺杆菌阳性患者中溃疡复发比例为62%，16例幽门螺杆菌阴性患者中溃疡复发比例为0%。关于幽门螺杆菌感染与瘢痕模式之间的关系，94%的幽门螺杆菌阴性患者表现为Sc型瘢痕模式，而所有幽门螺杆菌阳性患者表现出各种瘢痕模式，即38%为Sa型，28%为Sb型，10%为Sc型。幽门螺杆菌阳性病例中的溃疡复发仅限于Sa型和Sb型组（分别为100%和88%）。总之，我们的结果表明，幽门螺杆菌感染在与溃疡复发相关的溃疡瘢痕模式转变中起重要作用。
