Arning M, Heer-Sonderhoff A H, Wehmeier A, Schneider W
Heinrich-Heine-University Medical Center, Department of Haematology, Oncology and Clinical Immunology, Düsseldorf, Germany.
Eur J Clin Microbiol Infect Dis. 1995 Jan;14(1):41-3. doi: 10.1007/BF02112616.
Pulmonary toxicity with acute dyspnea occurred during infusion of a liposomal amphotericin B preparation (AmBisome) in two adult leukemic patients. The preparation was administered as a one hour infusion at a dose of 3 mg/kg body weight. Within 15 min after starting the infusion, both patients experienced sudden onset of dyspnea and chest tightness. Physical examination showed the patients to be anxious and restless with tachycardia and orthopnea but without other cardiopulmonary findings. No elevation of body temperature, rigors or chills were recorded. Symptoms disappeared within minutes after discontinuing the infusion. At present, the pathophysiologic mechanisms underlying these side effects are unknown.
两名成年白血病患者在输注脂质体两性霉素B制剂（安必素）期间出现伴有急性呼吸困难的肺部毒性。该制剂以3mg/kg体重的剂量进行1小时输注给药。在开始输注后15分钟内，两名患者均突然出现呼吸困难和胸闷。体格检查显示患者焦虑不安，有心动过速和端坐呼吸，但无其他心肺方面的表现。未记录到体温升高、寒战或发冷。停止输注后数分钟内症状消失。目前，这些副作用潜在的病理生理机制尚不清楚。
