Emminger W, Innerhofer A, Helfert A, Kummer M, Gadner H
St. Anna Kinderspital, Wien, Osterreich.
Padiatr Padol. 1992;27(4):97-9.
Amphotericin B (Amph-B) is the treatment of choice for systemic fungal infections. The application of high doses is limited due to the high incidence of acute side effects (fever, chills) and organ toxicity (reduction in glomerular filtration rate, renal tubular damage). Amph-B was applied without success in a three months old infant, who suffered from systemic candidiasis. After a change to high doses (3-5 mg/kg/day) of liposomal Amph-B (Amph-lip) rapid improvement of the patient's condition occurred and the pulmonary lesions disappeared during six weeks of treatment (total dose 185.5 mg/kg). Acute side effects or renal function abnormalities did not occur. The reported case indicates that the application of high doses of Amph-lip is an alternative to conventional Amph-B in treatment of systemic fungal infections.
两性霉素B（Amph - B）是治疗系统性真菌感染的首选药物。由于急性副作用（发热、寒战）和器官毒性（肾小球滤过率降低、肾小管损伤）的高发生率，高剂量应用受到限制。一名患有系统性念珠菌病的三个月大婴儿应用两性霉素B治疗未成功。改用高剂量（3 - 5毫克/千克/天）的脂质体两性霉素B（Amph - lip）后，患者病情迅速改善，在六周的治疗期间（总剂量185.5毫克/千克）肺部病变消失。未出现急性副作用或肾功能异常。该报告病例表明，高剂量的Amph - lip在治疗系统性真菌感染方面是传统两性霉素B的一种替代选择。
