Menegola E, Prati M, Broccia M L, Ricolfi R, Giavini E
Department of Biology, University of Milan, Italy.
Experientia. 1995 Apr 15;51(4):394-7. doi: 10.1007/BF01928903.
Rat embryos of 9.5 or 10 days of gestation were removed from control or streptozotocin-diabetic mothers and cultured in normal rat serum (180 mg% glucose) or in diabetic serum (600 mg% glucose). The development of control embryos in normal serum was adequate. Embryos from normal mothers cultured in diabetic serum showed signs of developmental retardation. The development of embryos obtained from diabetic mothers was severely impaired, regardless of the gestational age or the culture medium. These results suggest that a diabetic maternal milieu produces irreversible effects in the embryo very early in gestation.
将妊娠9.5天或10天的大鼠胚胎从对照或链脲佐菌素诱导的糖尿病母亲体内取出，在正常大鼠血清（葡萄糖含量180mg%）或糖尿病血清（葡萄糖含量600mg%）中培养。正常血清中对照胚胎发育正常。在糖尿病血清中培养的正常母亲的胚胎表现出发育迟缓的迹象。无论胎龄或培养基如何，糖尿病母亲所产胚胎的发育均严重受损。这些结果表明，糖尿病母亲的体内环境在妊娠早期就会对胚胎产生不可逆的影响。
