Houmard J A, Weidner M D, Dolan P L, Leggett-Frazier N, Gavigan K E, Hickey M S, Tyndall G L, Zheng D, Alshami A, Dohm G L
Human Performance Laboratory, School of Health and Human Performance, East Carolina University, Greenville, NC 27858, USA.
Diabetes. 1995 May;44(5):555-60. doi: 10.2337/diab.44.5.555.
The insulin resistance of aging has been attributed to a postreceptor defect in skeletal muscle. The present study examined whether a reduction in the concentration of the insulin-stimulated glucose transporter (GLUT4) in skeletal muscle was associated with advancing age in men (n = 55) and women (n = 29). Insulin sensitivity (minimal model) was negatively associated (P < 0.001) with age (range, 18-80 years) in men (r = -0.44) and women (r = -0.58). GLUT4 protein concentration in the vastus lateralis was also negatively associated (P < 0.05) with age (men, r = -0.28; women, r = -0.51). There was no relation (P > 0.15) between GLUT4 content in the gastrocnemius and age. GLUT4 concentration in the vastus lateralis was positively associated (P < 0.01) with insulin sensitivity in both sexes (r = 0.42); this relationship persisted in the men after adjusting for overall adiposity, regional adiposity, and cardiorespiratory fitness. These findings suggest that a decrement in GLUT4 protein concentration in skeletal muscle may at least partially contribute to the insulin resistance of aging in humans.
衰老引起的胰岛素抵抗被认为是由骨骼肌中受体后缺陷导致的。本研究调查了男性（n = 55）和女性（n = 29）骨骼肌中胰岛素刺激的葡萄糖转运蛋白（GLUT4）浓度降低是否与年龄增长相关。胰岛素敏感性（最小模型）在男性（r = -0.44）和女性（r = -0.58）中均与年龄（范围18 - 80岁）呈负相关（P < 0.001）。股外侧肌中GLUT4蛋白浓度也与年龄呈负相关（P < 0.05）（男性，r = -0.28；女性，r = -0.51）。腓肠肌中GLUT4含量与年龄之间无相关性（P > 0.15）。股外侧肌中GLUT4浓度在两性中均与胰岛素敏感性呈正相关（P < 0.01）（r = 0.42）；在调整总体肥胖、局部肥胖和心肺适能后，这种关系在男性中依然存在。这些发现表明，骨骼肌中GLUT4蛋白浓度的降低可能至少部分导致了人类衰老引起的胰岛素抵抗。
