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1
The genes for the Clostridium botulinum type G toxin complex are on a plasmid.G型肉毒梭菌毒素复合物的基因位于一个质粒上。
Infect Immun. 1995 May;63(5):2087-91. doi: 10.1128/iai.63.5.2087-2091.1995.
2
Plasmid encoded neurotoxin genes in Clostridium botulinum serotype A subtypes.A型肉毒梭菌亚型中的质粒编码神经毒素基因。
Biochem Biophys Res Commun. 2007 Sep 14;361(1):49-54. doi: 10.1016/j.bbrc.2007.06.166. Epub 2007 Jul 20.
3
Molecular analysis of an extrachromosomal element containing the C2 toxin gene discovered in Clostridium botulinum type C.对在C型肉毒梭菌中发现的含有C2毒素基因的一种染色体外元件的分子分析。
J Bacteriol. 2009 May;191(10):3282-91. doi: 10.1128/JB.01797-08. Epub 2009 Mar 6.
4
Molecular characterization of the clusters of genes encoding the botulinum neurotoxin complex in clostridium botulinum (Clostridium argentinense) type G and nonproteolytic Clostridium botulinum type B.肉毒梭菌（阿根廷肉毒梭菌）G型和非蛋白水解性B型肉毒梭菌中编码肉毒杆菌神经毒素复合物的基因簇的分子特征
Curr Microbiol. 1997 Oct;35(4):207-14. doi: 10.1007/s002849900240.
5
Nucleotide sequence of the gene coding for Clostridium botulinum (Clostridium argentinense) type G neurotoxin: genealogical comparison with other clostridial neurotoxins.编码肉毒梭菌（阿根廷肉毒梭菌）G型神经毒素的基因的核苷酸序列：与其他梭菌神经毒素的谱系比较。
Biochim Biophys Acta. 1993 Dec 14;1216(3):487-91. doi: 10.1016/0167-4781(93)90020-e.
6
The complete nucleotide sequence of the gene coding for the nontoxic-nonhemagglutinin component of Clostridium botulinum type C progenitor toxin.肉毒梭菌C型祖毒素无毒-无血凝素成分编码基因的完整核苷酸序列。
Biochem Biophys Res Commun. 1992 Mar 31;183(3):1273-9. doi: 10.1016/s0006-291x(05)80328-6.
7
Three classes of plasmid (47-63 kb) carry the type B neurotoxin gene cluster of group II Clostridium botulinum.三类质粒（47 - 63 kb）携带II型肉毒梭菌的B型神经毒素基因簇。
Genome Biol Evol. 2014 Aug;6(8):2076-87. doi: 10.1093/gbe/evu164.
8
Conserved structure of genes encoding components of botulinum neurotoxin complex M and the sequence of the gene coding for the nontoxic component in nonproteolytic Clostridium botulinum type F.肉毒杆菌神经毒素复合物M编码成分的基因保守结构以及非蛋白水解性F型肉毒杆菌中毒性成分编码基因的序列。
Curr Microbiol. 1994 Aug;29(2):69-77. doi: 10.1007/BF01575751.
9
Analysis of the botulinum neurotoxin type F gene clusters in proteolytic and nonproteolytic Clostridium botulinum and Clostridium barati.肉毒杆菌神经毒素F型基因簇在蛋白水解性和非蛋白水解性肉毒梭菌及巴氏梭菌中的分析。
Curr Microbiol. 1998 Oct;37(4):262-8. doi: 10.1007/s002849900376.
10
Characterization of nontoxic-nonhemagglutinin component of the two types of progenitor toxin (M and L) produced by Clostridium botulinum type D CB-16.D型肉毒梭菌CB - 16产生的两种祖毒素（M和L）的无毒-非血凝素成分的特性分析
Microbiol Immunol. 1995;39(7):457-65. doi: 10.1111/j.1348-0421.1995.tb02229.x.

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7
Detection of the HA-33 protein in botulinum neurotoxin type G complex by mass spectrometry.通过质谱法检测G型肉毒杆菌神经毒素复合物中的HA-33蛋白。
BMC Microbiol. 2015 Oct 23;15:227. doi: 10.1186/s12866-015-0567-5.
8
Genomic sequences of six botulinum neurotoxin-producing strains representing three clostridial species illustrate the mobility and diversity of botulinum neurotoxin genes.代表三种梭菌属物种的六个产肉毒杆菌神经毒素菌株的基因组序列说明了肉毒杆菌神经毒素基因的流动性和多样性。
Infect Genet Evol. 2015 Mar;30:102-113. doi: 10.1016/j.meegid.2014.12.002. Epub 2014 Dec 6.
9
Historical and current perspectives on Clostridium botulinum diversity.肉毒梭菌多样性的历史与当前观点
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10
Identification and genetic characterization of Clostridium botulinum serotype A strains from commercially pasteurized carrot juice.从商业巴氏杀菌胡萝卜汁中鉴定肉毒梭菌A血清型菌株并进行基因特征分析。
Food Microbiol. 2014 Dec;44:149-55. doi: 10.1016/j.fm.2014.05.009. Epub 2014 Jun 3.

本文引用的文献

1
The complete nucleotide sequence of the gene encoding the nontoxic component of Clostridium botulinum type E progenitor toxin.编码肉毒梭菌E型祖毒素无毒成分的基因的完整核苷酸序列。
J Gen Microbiol. 1993 Jan;139(1):79-86. doi: 10.1099/00221287-139-1-79.
2
Transfer of neurotoxigenicity from Clostridium butyricum to a nontoxigenic Clostridium botulinum type E-like strain.神经毒素产生能力从丁酸梭菌转移至一株非产毒的E型肉毒杆菌样菌株。
Appl Environ Microbiol. 1993 Nov;59(11):3825-31. doi: 10.1128/aem.59.11.3825-3831.1993.
3
Nucleotide sequence of the gene coding for Clostridium botulinum (Clostridium argentinense) type G neurotoxin: genealogical comparison with other clostridial neurotoxins.编码肉毒梭菌（阿根廷肉毒梭菌）G型神经毒素的基因的核苷酸序列：与其他梭菌神经毒素的谱系比较。
Biochim Biophys Acta. 1993 Dec 14;1216(3):487-91. doi: 10.1016/0167-4781(93)90020-e.
4
Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond.肉毒杆菌G型神经毒素在单个丙氨酸-丙氨酸肽键处切割VAMP/突触小泡蛋白。
J Biol Chem. 1994 Aug 12;269(32):20213-6.
5
Conserved structure of genes encoding components of botulinum neurotoxin complex M and the sequence of the gene coding for the nontoxic component in nonproteolytic Clostridium botulinum type F.肉毒杆菌神经毒素复合物M编码成分的基因保守结构以及非蛋白水解性F型肉毒杆菌中毒性成分编码基因的序列。
Curr Microbiol. 1994 Aug;29(2):69-77. doi: 10.1007/BF01575751.
6
Mechanism of action of tetanus and botulinum neurotoxins.破伤风和肉毒杆菌神经毒素的作用机制。
Mol Microbiol. 1994 Jul;13(1):1-8. doi: 10.1111/j.1365-2958.1994.tb00396.x.
7
Isolation of Clostridium botulinum type G and identification of type G botulinal toxin in humans: report of five sudden unexpected deaths.G型肉毒梭菌的分离及人体中G型肉毒毒素的鉴定：五例意外猝死报告
J Infect Dis. 1981 Jan;143(1):22-7. doi: 10.1093/infdis/143.1.22.
8
Simple and rapid method for isolating large plasmid DNA from lactic streptococci.从乳酸链球菌中分离大质粒DNA的简单快速方法。
Appl Environ Microbiol. 1983 Sep;46(3):549-52. doi: 10.1128/aem.46.3.549-552.1983.
9
Clostridium botulinum neurotoxin.肉毒梭菌神经毒素
Microbiol Rev. 1980 Sep;44(3):419-48. doi: 10.1128/mr.44.3.419-448.1980.
10
Another type of Clostridium botulinum.另一种肉毒梭菌。
Zentralbl Bakteriol Orig. 1970;215(2):221-4.

G型肉毒梭菌毒素复合物的基因位于一个质粒上。

The genes for the Clostridium botulinum type G toxin complex are on a plasmid.

作者信息

Zhou Y, Sugiyama H, Nakano H, Johnson E A

机构信息

Department of Food Microbiology, University of Wisconsin, Madison 53706, USA.

出版信息

Infect Immun. 1995 May;63(5):2087-91. doi: 10.1128/iai.63.5.2087-2091.1995.

DOI:10.1128/iai.63.5.2087-2091.1995
PMID:7729925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC173270/
Abstract

Clostridium botulinum type G produces a toxin complex that is composed of neurotoxin, hemagglutinin, and nontoxic nonhemagglutinin. The three genes encoding these proteins were closely linked on a plasmid of about 114 kb (76 MDa) but not on chromosomal DNA. In contrast to the genes of other C. botulinum serotypes, the genes encoding type G toxin are on a plasmid.

摘要

G型肉毒梭菌产生一种毒素复合物，该复合物由神经毒素、血凝素和无毒非血凝素组成。编码这些蛋白质的三个基因紧密连锁在一个约114 kb（76 MDa）的质粒上，而不在染色体DNA上。与其他肉毒梭菌血清型的基因不同，编码G型毒素的基因位于质粒上。