Deisenhammer F, Keir G, Pfausler B, Thompson E J
Institute of Neurology, London, UK.
J Neuroimmunol. 1996 May;66(1-2):85-93. doi: 10.1016/0165-5728(96)00029-x.
In this study, we investigated the affinity of anti-GM1 IgG antibodies as well as their IgG subclass distribution in a series of 38 patients with Guillain-Barré syndrome. In 7 sera elevated titres of IgG anti-GM1 antibodies could be detected. With respect to affinity there were two distinct groups of anti-GM1 antibodies: one group was of high affinity and did not cross-react with other glycolipids; the other group was of low affinity and cross-reacted with asialo-GM1. IgG1 was the predominant and almost exclusive subclass of high affinity anti-GM1 antibodies. Axonal degeneration occurred significantly more frequently in patients with high affinity anti-GM1 antibodies than in patients without anti-GM1 antibodies or in patients with low affinity anti-GM1 antibodies. The presence of anti-Campylobacter jejuni antibodies was not associated with a specific electrophysiological pattern. The prognosis was not dependent on the detection of any of the antibodies, whereas axonal loss and ventilation were associated with a poor prognosis.
在本研究中，我们调查了38例吉兰-巴雷综合征患者体内抗GM1 IgG抗体的亲和力及其IgG亚类分布情况。在7份血清中可检测到IgG抗GM1抗体的滴度升高。就亲和力而言，抗GM1抗体可分为两个不同的组：一组具有高亲和力，且不与其他糖脂发生交叉反应；另一组具有低亲和力，可与脱唾液酸GM1发生交叉反应。IgG1是高亲和力抗GM1抗体的主要且几乎唯一的亚类。与无抗GM1抗体的患者或低亲和力抗GM1抗体的患者相比，高亲和力抗GM1抗体的患者轴索性变性的发生率明显更高。抗空肠弯曲菌抗体的存在与特定的电生理模式无关。预后并不取决于任何一种抗体的检测结果，而轴索丢失和通气与预后不良相关。
