Mooney E E, Ruis Peris J M, O'Neill A, Sweeney E C
Department of Histopathology, St James's Hospital, Trinity College, Dublin, Ireland.
J Clin Pathol. 1995 Mar;48(3):242-4. doi: 10.1136/jcp.48.3.242.
To assess the relative frequency of mitotic and apoptotic cells in malignant melanoma and basal cell carcinoma.
Retrospective evaluation of haematoxylin and eosin stained slides from 10 basal cell carcinomas, 10 nodular melanomas, and 10 superficial spreading melanomas, with counting of apoptotic and mitotic cells per 1000 cells. Selected cases were studied with in situ end-labelling.
The ratio of apoptotic to mitotic cells was higher in basal cell carcinoma than in either form of melanoma because of the presence of a greater number of apoptotic cells in basal cell carcinoma.
The differing growth rates and biological behaviour of these two tumours is reflected in the apoptotic:mitotic ratio. Further assessment of this ratio is warranted, both between tumour types and between individual tumours of one type, to determine its value as an indicator of biological potential.
评估有丝分裂细胞和凋亡细胞在恶性黑色素瘤和基底细胞癌中的相对频率。
对10例基底细胞癌、10例结节性黑色素瘤和10例浅表扩散性黑色素瘤的苏木精和伊红染色切片进行回顾性评估，计算每1000个细胞中的凋亡细胞和有丝分裂细胞数量。对选定病例进行原位末端标记研究。
基底细胞癌中凋亡细胞与有丝分裂细胞的比例高于任何一种形式的黑色素瘤，因为基底细胞癌中存在更多的凋亡细胞。
这两种肿瘤不同的生长速率和生物学行为反映在凋亡:有丝分裂比例上。有必要对该比例在不同肿瘤类型之间以及同一类型的单个肿瘤之间进行进一步评估，以确定其作为生物学潜能指标的价值。
