Jacobs G H, Rippey J J, Altini M
Cancer. 1982 Feb 1;49(3):533-7. doi: 10.1002/1097-0142(19820201)49:3<533::aid-cncr2820490322>3.0.co;2-o.
In this study, a series of aggressively behaving basal cell carcinomas has been contrasted with a series of the nonaggressive type (metastasizing lesions were not considered in this study). Aggressive tumors were characteristically more likely to be ulcerative and infiltrative. They were composed of small groups of cells often displaying an irregular spiky appearance; infiltration of cells in cords, only one or two cells thick, could be seen. There was loss of peripheral palisading: the cells tended not to show differentiation. Hyalinization of the stroma was more common in the aggressive tumors. It is postulated that by utilizing these criteria, the pathologist can confidently diagnose the majority of cases and forewarn the clinician that a particular tumor is potentially aggressive. Adequate treatment and careful follow-up then become feasible.
在本研究中，将一系列具有侵袭性的基底细胞癌与一系列非侵袭性类型（本研究未考虑转移性病变）进行了对比。侵袭性肿瘤的特征通常是更易出现溃疡和浸润。它们由常呈现不规则棘状外观的小细胞团组成；可见细胞呈条索状浸润，仅一两个细胞厚。周边栅栏状排列消失：细胞往往不显示分化。基质透明变性在侵袭性肿瘤中更为常见。据推测，通过运用这些标准，病理学家能够自信地诊断大多数病例，并预先告知临床医生某一特定肿瘤可能具有侵袭性。这样就可以进行充分的治疗并进行仔细的随访。
