Fabrigoule C, Letenneur L, Dartigues J F, Zarrouk M, Commenges D, Barberger-Gateau P
INSERM U 330, Université de Bordeaux II, France.
J Am Geriatr Soc. 1995 May;43(5):485-90. doi: 10.1111/j.1532-5415.1995.tb06093.x.
To study the relationship between social and leisure activities and risk of subsequent dementia in older community residents.
A cohort study of people aged 65 and older were followed-up 1 and 3 years after a baseline screening (the Paquid study).
2040 older subjects living at home in Gironde (France) were randomly selected and followed for at least 3 years.
Information about social and leisure activities was collected during the baseline screening with an interview by a psychologist. Incident cases of dementia were detected during the first and third year follow-up screenings according to the DSM-III-R criteria.
All but one of the social and leisure activities noted were significantly associated with a lower risk of dementia. Only golden club participation was not significantly associated with this risk. After adjustment for age and cognitive performance measured by the Mini-Mental State Exam, visual memory test, and verbal fluency test, only traveling (Relative risk (RR) = .48,95% Confidence Interval (95% CI) = .24-.94), odd jobs or knitting (RR = .46,95% CI = .26-.85), and gardening (RR = .53, 95% CI = .28-.99) remained significant.
Regular participation in social or leisure activities such as traveling, odd jobs, knitting, or gardening were associated with a lower risk of subsequent dementia.
研究老年社区居民的社交和休闲活动与后续患痴呆症风险之间的关系。
一项对65岁及以上人群的队列研究在基线筛查（帕奎德研究）后1年和3年进行随访。
随机选取了2040名居住在法国吉伦特省家中的老年受试者，并对其进行了至少3年的随访。
在基线筛查期间，由一名心理学家通过访谈收集有关社交和休闲活动的信息。根据《精神疾病诊断与统计手册》第三版修订版标准，在第一年和第三年的随访筛查中检测痴呆症的发病病例。
除一项社交和休闲活动外，其他所有活动均与较低的痴呆症风险显著相关。只有参加黄金俱乐部与该风险无显著关联。在对年龄以及通过简易精神状态检查、视觉记忆测试和语言流畅性测试所测量的认知表现进行调整后，只有旅行（相对风险（RR）=0.48，95%置信区间（95%CI）=0.24 - 0.94）、零工或编织（RR = 0.46，95%CI = 0.26 - 0.85）以及园艺（RR = 0.53，95%CI = 0.28 - 0.99）仍具有显著性。
定期参与社交或休闲活动，如旅行、零工、编织或园艺，与后续患痴呆症的风险较低相关。
