Tamura J, Jinbo T, Itoh K, Take H, Matsushima T, Murakami H, Kubota K, Tsuchiya J, Naruse T
Third Department of Internal Medicine, Gunma University School of Medicine, Japan.
J Med. 1994;25(5):337-40.
We describe a 31-year-old patient with ulcerative colitis who was successfully treated with prednisolone (PSL). Immunologic analyses were performed during the treatment course. Suppressed natural killer (NK) cell activity and increased levels of the CD4/CD8 ratio were observed on admission. Transient restoration of NK cell activity was obtained by PSL treatment. However, it returned to the initial low level in spite of the improvement of clinical symptoms. Possible mechanisms are discussed for involvement of the immune system in the pathogenesis of ulcerative colitis (UC).
我们描述了一名31岁的溃疡性结肠炎患者，其通过泼尼松龙（PSL）治疗成功。在治疗过程中进行了免疫学分析。入院时观察到自然杀伤（NK）细胞活性受到抑制，CD4/CD8比值升高。PSL治疗使NK细胞活性得到短暂恢复。然而，尽管临床症状有所改善，其仍恢复到最初的低水平。本文讨论了免疫系统参与溃疡性结肠炎（UC）发病机制的可能机制。
