用双异丙基氟磷酸酯使豚鼠各组织中的胆碱酯酶失活后，观察其被氯解磷定重新激活的情况，对各组织中的胆碱酯酶进行表征。 - Suppr

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超能文献

Characterization of cholinesterases in various tissues of guinea pig with respect to their reactivation by obidoxime after inactivation by diisopropylfluorophosphate.

作者信息

Alsen C, Ohnesorge F K

出版信息

Arch Toxikol. 1972;29(3):235-45. doi: 10.1007/BF00315601.

DOI:10.1007/BF00315601

PMID:4566010

Abstract

摘要

相似文献

Characterization of cholinesterases in various tissues of guinea pig with respect to their reactivation by obidoxime after inactivation by diisopropylfluorophosphate.用双异丙基氟磷酸酯使豚鼠各组织中的胆碱酯酶失活后，观察其被氯解磷定重新激活的情况，对各组织中的胆碱酯酶进行表征。

Arch Toxikol. 1972;29(3):235-45. doi: 10.1007/BF00315601.

Effects of DFP and obidoxime on brain acetylcholine levels on brain and peripheral cholinesterases.二异丙基氟磷酸酯（DFP）和双复磷对脑乙酰胆碱水平以及脑和外周胆碱酯酶的影响。

Biochem Pharmacol. 1971 Nov;20(11):3029-37. doi: 10.1016/0006-2952(71)90107-9.

Effects of obidoxime on content and synthesis of brain acetylcholine in DFP intoxicated rats.双复磷对二异丙基氟磷酸酯中毒大鼠脑乙酰胆碱含量及合成的影响。

Biochem Pharmacol. 1973 Dec 1;22(23):3124-7. doi: 10.1016/0006-2952(73)90202-5.

[Reactivation by aliphatic alpha-hydroxyimino-ketones of plasma cholinesterases inhibited by diisopropylfluorophosphate, in Wistar rats].[在Wistar大鼠中，脂肪族α-羟基亚氨基酮对被二异丙基氟磷酸酯抑制的血浆胆碱酯酶的重新激活作用]

C R Acad Hebd Seances Acad Sci D. 1974 Jun 24;278(26):3391-3.

Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6.两种新型不对称双吡啶肟（K-27和K-48）对暴露于二异丙基氟磷酸酯的大鼠的疗效：与解磷定、双复磷、三甲肟、甲氧肟和HI-6的比较。

Toxicol Mech Methods. 2009 May;19(4):327-33. doi: 10.1080/15376510902798695.

In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs.在豚鼠体内，经神经毒剂暴露后，肟类化合物对血液、脑和周围组织胆碱酯酶活性的抑制作用的体内再激活。

Chem Biol Interact. 2010 Sep 6;187(1-3):207-14. doi: 10.1016/j.cbi.2010.03.006. Epub 2010 Mar 9.

The effect of locally applied cholinesterase inhibitors and oximes on the acetylcholinesterase activity in different parts of the guinea-pig eye.局部应用胆碱酯酶抑制剂和肟对豚鼠眼不同部位乙酰胆碱酯酶活性的影响。

Acta Pharmacol Toxicol (Copenh). 1976 Apr;38(4):299-307. doi: 10.1111/j.1600-0773.1976.tb03124.x.

Acetylcholine and cholinesterase in submandibular glands of rats given armin and obidoxime.给予阿米诺明和双复磷的大鼠下颌下腺中的乙酰胆碱和胆碱酯酶

J Dent Res. 1978 May-Jun;57(5-6):748-51. doi: 10.1177/00220345780570051801.

Obidoxime reactivation of organophosphate-inhibited cholinesterase activity in pigs.双复磷对猪体内有机磷酸酯抑制的胆碱酯酶活性的重新激活作用。

Acta Vet Scand. 1984;25(1):86-95. doi: 10.1186/BF03547282.

[Inhibition of cholinesterase activity in erythrocytes, ventricular muscle and brain of guinea pigs by subchronic and acute poisoning with diisopropylphosphofluoridate (DFP) and its reactivation of obidoxime].[二异丙基氟磷酸酯（DFP）亚慢性和急性中毒对豚鼠红细胞、心室肌和脑胆碱酯酶活性的抑制作用及其与双复磷的重新激活作用]

Arch Toxikol. 1970;26(2):102-16.

本文引用的文献

Selective inhibition of pseudo-cholinesterase by diisopropyl fluorophosphonate.二异丙基氟磷酸酯对假性胆碱酯酶的选择性抑制作用。

Br J Pharmacol Chemother. 1947 Sep;2(3):173-80. doi: 10.1111/j.1476-5381.1947.tb00334.x.

The distribution of cholinesterase types in mammalian tissues.哺乳动物组织中胆碱酯酶类型的分布。

Biochem J. 1950 Mar;46(3):346-52. doi: 10.1042/bj0460346.

The significance of butyrylcholine in the testing of cholinesterase-containing preparations.丁酰胆碱在含胆碱酯酶制剂检测中的意义。

Acta Brevia Neerl Physiol Pharmacol Microbiol E A. 1949;17(1-4):32-6.

Pseudocholinesterase activity in the central nervous system.中枢神经系统中的假性胆碱酯酶活性。

Biochem J. 1952 May;51(2):245-51. doi: 10.1042/bj0510245.

Reactivation of phosphorylated acetocholinesterases by pyridinium aldoximes and related compounds.吡啶醛肟及相关化合物对磷酸化乙酰胆碱酯酶的重新激活作用。

Biochem J. 1960 May;75(2):363-72. doi: 10.1042/bj0750363.

The characterization of tissue cholinesterases.组织胆碱酯酶的特性

Biochim Biophys Acta. 1955 Apr;16(4):513-9. doi: 10.1016/0006-3002(55)90271-7.

Chemical reactivation of phosphorylated human and bovine true cholinesterases.磷酸化人及牛真性胆碱酯酶的化学再活化

Br J Pharmacol Chemother. 1956 Sep;11(3):295-303. doi: 10.1111/j.1476-5381.1956.tb01069.x.

The kinetics of reactivation, by oximes, of cholinesterase inhibited by organophosphorus compounds.肟对有机磷化合物抑制的胆碱酯酶的复活动力学。

Biochem J. 1956 Aug;63(4):529-35. doi: 10.1042/bj0630529.

Factors influencing the rate of "aging" of a series of alkyl methylphosphonyl-acetylcholinesterases.影响一系列烷基甲基膦酰基 - 乙酰胆碱酯酶“老化”速率的因素。

Biochem J. 1966 Aug;100(2):572-6. doi: 10.1042/bj1000572.

Measurement of the affinity and phosphorylation constants governing irreversible inhibition of cholinesterases by di-isopropyl phosphorofluoridate.对二异丙基氟磷酸酯不可逆抑制胆碱酯酶的亲和力和磷酸化常数的测定。

Biochem J. 1966 Aug;100(2):525-31. doi: 10.1042/bj1000525.

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