Ordi Ros J, Falgà Tirado C, Monegal Ferran F, Selva O'Callaghan A, Pérez Pemán P, Cucurull E, Vilardell Tarres M
Servicio de Medicina Interna, Hospital General Universitari Vall d'Hebron, Barcelona.
Med Clin (Barc). 1995 Feb 25;104(7):245-8.
Anti-beta 2-glycoprotein I antibodies (a beta 2GPI) were studied in patients with diseases or clinical symptoms related to antiphospholipid antibodies (aPl) with the aim of establishing a relationship between both antibodies and these clinical manifestations.
The a beta 2GPI antibodies were determined by enzymeimmunoassay in a group of 94 altruist blood donors and 135 patients (98 with systemic lupus erythematosus, 21 cases of primary antiphospholipid syndrome, 10 cases with idiopathic Sneddon syndrome and 6 with Q fever). The lupus anticoagulating-type aPl antibodies were determined in the same subjects by kaolin coagulation time and the Russell's viper venom time while anticardiolipin-type IgG, IgM and IgA isotypes were determined by enzymeimmunoassay. The a beta 2GPI antibodies were related with the aPl antibodies, fetal losses and history of thrombosis by a contingency table with Yates correction in the first two parameters and means comparison by the Students' t test for the history of thrombosis.
The aPl and a beta 2GPI antibodies in the control group were negative. In the group of patients the latter antibodies were positive in 33.6% (33 cases) of the patients with lupus, 57% (12 cases) of the patients with primary antiphospholipid syndrome, in one of the patients with the Sneddon syndrome and in none of the patients with Q fever. The aPl antibodies were positive in 26.5% of the patients with lupus and in 100% of the cases with primary antiphospholipid syndrome or Q fever and negative in all the cases with idiopathic Sneddon syndrome. A significant relationship was found between the a beta 2GPI antibodies and thrombotic manifestations (p = 0.01) or obstetric complications (p < 0.04). A dependent relationship was observed in both autoantibodies (aPl and a beta 2GPI) (p < 0.01).
There is a significant relationship between the antiphospholipid antibodies and the anti-beta 2-glycoprotein I antibodies in addition to a relationship with thrombotic symptoms or obstetric complications.
对患有与抗磷脂抗体（aPl）相关疾病或临床症状的患者进行了抗β2糖蛋白I抗体（aβ2GPI）研究，目的是确定这两种抗体与这些临床表现之间的关系。
采用酶免疫分析法对94名无偿献血者和135名患者（98例系统性红斑狼疮患者、21例原发性抗磷脂综合征患者、10例特发性斯内登综合征患者和6例Q热患者）检测aβ2GPI抗体。采用高岭土凝血时间和蝰蛇毒时间对同一组受试者检测狼疮抗凝型aPl抗体，采用酶免疫分析法检测抗心磷脂型IgG、IgM和IgA同种型抗体。通过列联表（前两个参数采用耶茨校正）将aβ2GPI抗体与aPl抗体、胎儿丢失及血栓形成史进行关联分析，采用学生t检验对血栓形成史进行均值比较。
对照组的aPl和aβ2GPI抗体均为阴性。在患者组中，狼疮患者中33.6%（33例）的后者抗体呈阳性，原发性抗磷脂综合征患者中57%（12例）呈阳性，1例斯内登综合征患者呈阳性，Q热患者均为阴性。狼疮患者中26.5%的aPl抗体呈阳性，原发性抗磷脂综合征或Q热患者中100%呈阳性，特发性斯内登综合征患者均为阴性。发现aβ2GPI抗体与血栓形成表现（p = 0.01）或产科并发症（p < 0.04）之间存在显著关系。观察到两种自身抗体（aPl和aβ2GPI）之间存在依赖关系（p < 0.01）。
抗磷脂抗体与抗β2糖蛋白I抗体之间存在显著关系，此外还与血栓形成症状或产科并发症有关。
