用大肠杆菌脂多糖（LPS）处理的小鼠胸腺中的细胞选择。

Cell selection in the thymus of mice treated with escherichia coli lipopolysaccharide (LPS).

作者信息

Uccini S, Ruco L, Soravito G, Adorini L, Doria G, Baroni C D

出版信息

Adv Exp Med Biol. 1976;66:95-9. doi: 10.1007/978-1-4613-4355-4_14.

Abstract

The present data indicate that injection of LPS induces a decrease in thymus weight with selection of thymocytes more efficient in killer and helper activities. It has been reported (12) that two T-cell types may cooperate in the GVH reaction: the effector T1 and the amplifier T2. The maturation from T1 to T2 occurs mainly in the periphery, whereas immature cortex thymocytes differentiate to T1 within the thymus (13). Our results, showing an LPS-dependent enhancement of thymocyte killing activity, suggest that LPS selects thymocytes mostly of the T1 type. LPS-treated thymocytes are more efficient in the reconstitution of the anti-SRBC response. These data can be explained considering that LPS, like cortisone (14), enriches the thymus with more immunocompetent helper cells. Alternatively it may be suggested that LPS selects in the thymus cell populations characterized by high proliferative activity. Unpublished observations showing that LPS-treatment in vivo increases the in vitro response of thymocytes to Con-A are consistent with this interpretation.

摘要

目前的数据表明，注射脂多糖（LPS）会导致胸腺重量减轻，同时选择出在杀伤和辅助活性方面更高效的胸腺细胞。据报道（12），两种T细胞类型可能在移植物抗宿主反应（GVH反应）中协同作用：效应T1细胞和放大T2细胞。从T1到T2的成熟主要发生在外周，而未成熟的皮质胸腺细胞在胸腺内分化为T1细胞（13）。我们的结果显示LPS依赖性增强胸腺细胞杀伤活性，这表明LPS主要选择T1型胸腺细胞。经LPS处理的胸腺细胞在抗绵羊红细胞（SRBC）反应的重建中更高效。考虑到LPS与可的松（14）一样，会使胸腺中富含更多具有免疫活性的辅助细胞，这些数据可以得到解释。或者也可以认为，LPS在胸腺中选择具有高增殖活性的细胞群体。未发表的观察结果表明，体内LPS处理会增加胸腺细胞对刀豆蛋白A（Con-A）的体外反应，这与该解释一致。