Mac-Moune Lai F, Li E K, Tang N L, Li P K, Lui S F, Lai K N
Department of Anatomical and Cellular Pathology and Medicine, Chinese University of Hong Kong, Shatin.
Mod Pathol. 1995 Jan;8(1):5-10.
We describe three patients with a well-established clinical diagnosis of systemic lupus erythematosus in whom the renal biopsy lesion unexpectedly is diagnostic of IgA nephropathy, not superimposed with any features of lupus nephritis. Whereas the clinical presentation and follow-up of renal disease in these patients indicate a relatively indolent course, the extrarenal manifestations of systemic lupus erythematosys have been relatively severe, and one patient died of systemic infection. IgA nephropathy hitherto has not been described in patients with systemic lupus erythematosus, and such an observation stresses that atypical glomerular lesions in these patients should raise the possibility of a nonlupus glomerulopathy.
我们描述了3例临床确诊为系统性红斑狼疮的患者，其肾活检病变意外诊断为IgA肾病，未叠加任何狼疮性肾炎特征。尽管这些患者肾脏疾病的临床表现和随访显示病程相对缓慢，但系统性红斑狼疮的肾外表现相对严重，1例患者死于全身感染。此前尚未在系统性红斑狼疮患者中描述过IgA肾病，这一观察结果强调，这些患者中出现非典型肾小球病变应提高非狼疮性肾小球病的可能性。
