Tsega E, Gebre W, Manley P, Asfaw T
Department of Pathology, Faculty of Medicine, Addis Ababa University, Addis Ababa.
Ethiop Med J. 1996 Apr;34(2):65-71.
The aim of this study is to find out the prevalence of Helicobacter pylori infection in patients with nonulcer dyspepsia (NUD) and asymptomatic controls and to see if there is an etiological association between gastritis, NUD and Helicobacter pylori. One hundred thirty six patients with NUD and 71 controls had six endoscopic biopsies from different sites of the gastric mucosa for histological diagnosis. Helicobacter pylori was looked for in all biopsy specimens utilizing half Gram, Giemsa and Gimenez staining techniques. Type B chronic gastritis was detected in 96% of the NUD cases and in 100% of the asymptomatic controls (P > 0.05). Helicobacter pylori was found in 82 (65%) patients with NUD and in 38 (56%) asymptomatic controls (P > 0.05). Type B chronic gastritis is almost universal in both NUD cases and asymptomatic controls. There is no difference in the prevalence of Helicobacter pylori infection between the two groups. The absence of Helicobacter pylori in a significant number of patients (36%) and controls (45%) with gastritis contradicts the etiological association between Helicobacter pylori and gastritis reported by others, suggesting that in Ethiopia there may be a chronic environmental gastritis which may not be helicobacter-related. There is no correlation between NUD and Type B gastritis, and between symptoms and Helicobacter pylori infection in this population.
本研究旨在查明非溃疡性消化不良（NUD）患者和无症状对照人群中幽门螺杆菌感染的患病率，并探究胃炎、NUD与幽门螺杆菌之间是否存在病因学关联。136例NUD患者和71例对照者接受了来自胃黏膜不同部位的6次内镜活检，以进行组织学诊断。采用半革兰氏染色、吉姆萨染色和吉门尼斯染色技术，在所有活检标本中查找幽门螺杆菌。96%的NUD病例和100%的无症状对照者检测出B型慢性胃炎（P>0.05）。82例（65%）NUD患者和38例（56%）无症状对照者检测出幽门螺杆菌（P>0.05）。B型慢性胃炎在NUD病例和无症状对照者中几乎普遍存在。两组之间幽门螺杆菌感染的患病率没有差异。相当数量的胃炎患者（36%）和对照者（45%）中未检测出幽门螺杆菌，这与其他人报道的幽门螺杆菌与胃炎之间的病因学关联相矛盾，表明在埃塞俄比亚可能存在一种与幽门螺杆菌无关的慢性环境性胃炎。在该人群中，NUD与B型胃炎之间以及症状与幽门螺杆菌感染之间均无相关性。
