泮托拉唑在治疗急性胃溃疡方面优于雷尼替丁。

Pantoprazole is superior to ranitidine in the treatment of acute gastric ulcer.

作者信息

Hotz J, Plein K, Schönekäs H, Rose K

机构信息

Dept. of Medicine, Allgemeines Krankenhaus Celle, Germany.

出版信息

Scand J Gastroenterol. 1995 Feb;30(2):111-5. doi: 10.3109/00365529509093247.

DOI:10.3109/00365529509093247

PMID:7732331

Abstract

BACKGROUND

Pantoprazole is a newly developed gastric H+/K(+)-adenosine triphosphatase inhibitor with a potent and long-acting inhibitory effect on gastric acid secretion.

METHODS

In a double-blind multicenter study with 28 centers in Germany, pantoprazole (40 mg before breakfast) was compared with ranitidine (300 mg at bedtime) with regard to healing rates, time until healing, symptom relief, and tolerability. A total of 248 outpatients with benign gastric ulcer were included.

RESULTS

The healing rates after 2, 4, and 8 weeks were 37%, 87%, and 97%, respectively, in the pantoprazole and 19%, 58%, and 80% in the ranitidine group. The differences between the two groups were significant at 2 weeks (p < 0.01), 4 weeks (p < 0.001), and 8 weeks (p < 0.001; Cochran/Mantel-Haenszel method). Ulcer healing proceeded significantly faster with pantoprazole (p < 0.001; Uleman's U-test). Both treatments were well tolerated.

CONCLUSIONS

Pantoprazole appears to be superior to ranitidine in gastric ulcer healing.

摘要

背景

泮托拉唑是一种新开发的胃H⁺/K⁺-腺苷三磷酸酶抑制剂，对胃酸分泌具有强效且长效的抑制作用。

方法

在德国28个中心进行的一项双盲多中心研究中，比较了泮托拉唑（早餐前40毫克）与雷尼替丁（睡前300毫克）在愈合率、愈合时间、症状缓解和耐受性方面的差异。共纳入248例患有良性胃溃疡的门诊患者。

结果

泮托拉唑组在2周、4周和8周后的愈合率分别为37%、87%和97%，雷尼替丁组分别为19%、58%和80%。两组之间在2周（p<0.01）、4周（p<0.001）和8周（p<0.001； Cochr an/Mantel-Haenszel法）时差异显著。泮托拉唑治疗溃疡愈合明显更快（p<0.001；Uleman's U检验）。两种治疗耐受性均良好。