Fuse Y, Masuyama J, Yoshio T, Mimori A, Takeda A, Minota S, Kano S
Division of Clinical Immunology, Jichi Medical School, Tochigi.
Ryumachi. 1995 Feb;35(1):25-31.
The coincidence rate of cancer and PSS has been increasing according to reports from Nippon Byori Boken Shuho (Annual of Pathological Autopsy Cases in Japan), reaching 12.3% in the most recent report. Therefore we reviewed the histories of 67 PSS patients seen at our division over an 18-year period between 1974 and 1992, and found a high coincidence rate (14.6%) of cancer, reflecting the increasing tendency reported in the Nippon Byori Boken Shuho. The most frequent type of cancer was gastrointestinal cancer, including gastric and colon cancer and duodenal carcinoid. There were no significant differences in the clinical and laboratory findings between PSS patients with cancer and those without. Twenty-six of the 67 PSS patients died. Cancer was the cause of death in four, ranking second behind respiratory failure. The reason for the increasing coincidence rate of cancer and PSS is unclear at present. However, it is very important to discover cancer in PSS patients as early as possible, since it has a marked effect on prognosis.
根据《日本病理尸检病例年报》的报道，癌症与原发性胆汁性肝硬化（PSS）的并发率一直在上升，在最近的报告中达到了12.3%。因此，我们回顾了1974年至1992年这18年间在我科室就诊的67例PSS患者的病史，发现癌症的并发率很高（14.6%），这反映了《日本病理尸检病例年报》中报道的上升趋势。最常见的癌症类型是胃肠道癌，包括胃癌、结肠癌和十二指肠类癌。患有癌症的PSS患者与未患癌症的患者在临床和实验室检查结果上没有显著差异。67例PSS患者中有26例死亡。癌症是4例患者的死因，在死因中排名第二，仅次于呼吸衰竭。目前，癌症与PSS并发率上升的原因尚不清楚。然而，尽早在PSS患者中发现癌症非常重要，因为这对预后有显著影响。
