Pedersen H D, Koch J, Bie P, Jensen A L, Flagstad A
Clinical Department, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Zentralbl Veterinarmed A. 1994 Nov;41(9):713-6. doi: 10.1111/j.1439-0442.1994.tb00140.x.
Eight clinically healthy male beagle dogs received a low sodium diet for 5 weeks. Before and after this period the dogs received a control diet for 3 weeks. Both diets provided the dogs with approximately 6.8 mmol K+/kg/day. Neither introducing nor withdrawing the low sodium diet changed the plasma concentrations of endothelin-1 (ET-1), atrial natriuretic peptide (ANP) and arginine vasopressin (AVP). Pooled data from the control periods were not different from the low sodium period for either ET-1 (2.31 pg/ml and 2.09 pg/ml, P = 0.21), ANP (42.51 pg/ml and 38.99 pg/ml, P = 0.44) or AVP (4.14 pg/ml and 4.16 pg/ml, P = 0.91). It was concluded that ET-1, ANP and AVP in normal dogs are unaffected by a 6-fold change in sodium intake in the presence of a high potassium intake.
八只临床健康的雄性比格犬接受了为期5周的低钠饮食。在此期间之前和之后，这些犬接受了为期3周的对照饮食。两种饮食都为犬提供约6.8 mmol K⁺/kg/天的钾。引入或停用低钠饮食均未改变血浆内皮素-1（ET-1）、心钠素（ANP）和精氨酸加压素（AVP）的浓度。对照期的汇总数据与低钠期相比，ET-1（2.31 pg/ml和2.09 pg/ml，P = 0.21）、ANP（42.51 pg/ml和38.99 pg/ml，P = 0.44）或AVP（4.14 pg/ml和4.16 pg/ml，P = 0.91）均无差异。得出的结论是，在高钾摄入情况下，正常犬的ET-1、ANP和AVP不受钠摄入量6倍变化的影响。
