Pedersen H D, Koch J, Jensen A L, Poulsen K, Flagstad A
Small Animal Hospital, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
Acta Vet Scand. 1994;35(2):133-40. doi: 10.1186/BF03548340.
Eight normal male Beagle dogs received 0.7 mmol Na+/kg/day for 5 weeks and 4.0 mmol Na+/kg/day in one 3 week control period preceding and another similar period following the low sodium period. The dogs received 6.8 mmol K+/kg/day throughout the study. The median plasma renin activity (PRA) and plasma aldosterone concentration (PAC) were higher in the low sodium period than in the following control period (0.67 versus 0.28 ng/ml/h, p < 0.0001) and (204 versus 31 pg/ml, p < 0.0001). PRA and PAC quickly stabilized on a new steady level in response to altered intake of sodium chloride. The angiotensin-converting enzyme (ACE) activity was not changed by the altered intake of sodium chloride. The plasma concentrations of sodium and chloride were increased during the low sodium period. This could be due to an indirect effect of the high potassium intake of the dogs. Potassium leads to an increased secretion of aldosterone and thereby to an increased retention of sodium and chloride in the kidney. The possible implications of a high potassium content in a low sodium diet are discussed.
8只正常雄性比格犬在5周内每日接受0.7 mmol Na⁺/kg的摄入量，在低钠期之前和之后各有一个为期3周的对照期，期间每日接受4.0 mmol Na⁺/kg的摄入量。在整个研究过程中，这些犬每日接受6.8 mmol K⁺/kg的摄入量。低钠期的血浆肾素活性（PRA）和血浆醛固酮浓度（PAC）中位数高于随后的对照期（分别为0.67对0.28 ng/ml/h，p < 0.0001）以及（204对31 pg/ml，p < 0.0001）。随着氯化钠摄入量的改变，PRA和PAC迅速稳定在一个新的稳定水平。氯化钠摄入量的改变并未改变血管紧张素转换酶（ACE）的活性。低钠期血浆钠和氯的浓度升高。这可能是由于犬高钾摄入量的间接影响。钾会导致醛固酮分泌增加，从而使肾脏中钠和氯的潴留增加。本文讨论了低钠饮食中高钾含量的潜在影响。
